School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Engineering Campus, 14300 Nibong Tebal, Penang, Malaysia.
Department of Chemistry, Abdul Wali Khan University Mardan, 23200 Pakistan.
Int J Biol Macromol. 2018 Mar;108:367-375. doi: 10.1016/j.ijbiomac.2017.12.021. Epub 2017 Dec 6.
In this study, chitosan-poly(methacrylic acid-co-N-isopropylacrylamide) [chitosan-p(MAA-co-NIPAM)] hydrogels were synthesized by emulsion polymerization. In order to be used as a carrier for drug delivery systems, the hydrogels had to be biocompatible, biodegradable and multi-responsive. The polymerization was performed by copolymerize MAA and NIPAM with chitosan polymer to produce a chitosan-based hydrogel. Due to instability during synthesis and complexity of components to produce the hydrogel, further study at different times of reaction is important to observe the synthesis process, the effect of end product on swelling behaviour and the most important is to find the best way to control the hydrogel synthesis in order to have an optimal swelling behaviour for drug release application. Studied by using Fourier transform infra-red (FTIR) spectroscopy found that, the synthesized was successfully produced stable chitosan-based hydrogel with PNIPAM continuously covered the outer surface of hydrogel which influenced much on the stability during synthesis. The chitosan and PMAA increased the zeta potential of the hydrogel and the chitosan capable to control shrinkage above human body temperature. The chitosan-p(MAA-co-NIPAM) hydrogels also responses to pH and temperature thus improved the ability to performance as a drug carrier.
在这项研究中，通过乳液聚合合成了壳聚糖-聚（甲基丙烯酸-co-N-异丙基丙烯酰胺）[壳聚糖-p（MAA-co-NIPAM）]水凝胶。为了将其用作药物传递系统的载体，水凝胶必须具有生物相容性、可生物降解性和多重响应性。聚合是通过将 MAA 和 NIPAM 与壳聚糖聚合物共聚来进行的，以生产基于壳聚糖的水凝胶。由于在合成过程中不稳定以及产生水凝胶的成分复杂，因此在不同的反应时间进一步研究对于观察合成过程、最终产物对溶胀行为的影响以及最重要的是找到控制水凝胶合成的最佳方法以获得最佳的溶胀行为，从而实现药物释放应用是很重要的。通过使用傅里叶变换红外（FTIR）光谱研究发现，成功地合成了稳定的基于壳聚糖的水凝胶，PNIPAM 连续覆盖水凝胶的外表面，这对合成过程中的稳定性有很大影响。壳聚糖和 PMAA 增加了水凝胶的zeta 电位，壳聚糖能够控制高于人体温度的收缩。壳聚糖-p（MAA-co-NIPAM）水凝胶还对 pH 值和温度有响应，从而提高了作为药物载体的性能。
