从海洋海绵来源的枝孢属真菌Cladosporium sp. SCSIO41007中分离得到三种新的高氧化甾醇和一种新的二氢异香豆素。
Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp. SCSIO41007.
作者信息
Pang Xiaoyan, Lin Xiuping, Wang Junfeng, Liang Rui, Tian Yongqi, Salendra Limbadri, Luo Xiaowei, Zhou Xuefeng, Yang Bin, Tu Zhengchao, Liu Yonghong
机构信息
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China; University of Chinese Academy of Sciences, Beijing, China.
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
出版信息
Steroids. 2018 Jan;129:41-46. doi: 10.1016/j.steroids.2017.12.001. Epub 2017 Dec 6.
Three new highly oxygenated sterols (1-3) and a new dihydroisocoumarin (7) together with six known compounds were isolated from the extracts of the culture of a sponge-derived fungus Cladosporium sp. SCSIO41007. The structures of all new compounds (1-3, 7) were determined by the extensive spectroscopic analysis including NMR, MS, IR, and UV. Their absolute configurations were determined by X-ray single-crystal and CD data analysis. Compound 2 exhibited weak inhibitory activity against H3N2 with the IC value of 16.2 μM.
从海绵来源的真菌枝孢菌属Cladosporium sp. SCSIO41007的培养物提取物中分离出三种新的高氧化甾醇（1-3）、一种新的二氢异香豆素（7）以及六种已知化合物。所有新化合物（1-3、7）的结构通过包括核磁共振（NMR）、质谱（MS）、红外光谱（IR）和紫外光谱（UV）在内的广泛光谱分析确定。它们的绝对构型通过X射线单晶和圆二色（CD）数据分析确定。化合物2对H3N2表现出微弱的抑制活性，IC值为16.2 μM。
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