The Genus : A Prospective Producer of Natural Products.

, a genus of ascomycete fungi in the family, is primarily recognized as a widespread environmental saprotrophic fungus or plant endophyte. Further research has shown that the genus is distributed in various environments, particularly in marine ecosystems, such as coral reefs, mangroves and the polar region. , especially the marine-derived , is a highly resourceful group of fungi whose natural products have garnered attention due to their diverse chemical structures and biological activities, as well as their potential as sources of novel leads to compounds for drug production. This review covers the sources, distribution, bioactivities, biosynthesis and structural characteristics of compounds isolated from in the period between January 2000 and December 2022, and conducts a comparative analysis of the isolated compounds derived from marine and terrestrial sources. Our results reveal that 34% of -derived natural products are reported for the first time. And 71.79% of the first reported compounds were isolated from marine-derived . -derived compounds exhibit diverse skeletal chemical structures, concentrating in the categories of polyketides (48.47%), alkaloids (19.21%), steroids and terpenoids (17.03%). Over half of the natural products isolated from have been found to have various biological activities, including cytotoxic, antibacterial, antiviral, antifungal and enzyme-inhibitory activities. These findings testify to the tremendous potential of , especially the marine-derived , to yield novel bioactive natural products, providing a structural foundation for the development of new drugs.