Adult Histopathology, Department of Cellular Pathology, Central Manchester University Hospitals Foundation Trust, Clinical Sciences Building 1, Oxford Road, Manchester, M13 9WL, United Kingdom.
MMPathIC, The Manchester MRC/EPSRC Molecular Pathology Node, Faculty of Biology, Medicine, and Health, University of Manchester, and Manchester NIHR Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, M13 9NQ, United Kingdom.
Best Pract Res Clin Rheumatol. 2017 Apr;31(2):203-217. doi: 10.1016/j.berh.2017.09.003. Epub 2017 Oct 14.
This review aims to provide a summary of current concepts of ageing in relation to the musculoskeletal system, highlighting recent advances in the understanding of the mechanisms involved in the development of age-related changes in bone, skeletal muscle, chondroid and fibrous tissues. The key components of the musculoskeletal system and their functions are introduced together with a general overview of the molecular hallmarks of ageing. A brief description of the normal architecture of each of these tissue types is followed by a summary of established and developing concepts of mechanisms contributing to the age-related alterations in each. Extensive detailed description of these changes is beyond the scope of this review; instead, we aim to highlight some of the most significant processes and, where possible, the molecular changes underlying these and refer the reader to in-depth, subspecialist reviews of the individual components for further details.
本篇综述旨在概述与肌肉骨骼系统相关的衰老观念，强调理解骨骼、骨骼肌、软骨和纤维组织随年龄变化的机制方面的最新进展。本文首先介绍肌肉骨骼系统的关键组成部分及其功能，并概述衰老的分子特征。接下来简述这些组织类型的正常结构，然后总结导致各组织类型随年龄变化的机制的现有和新兴概念。由于无法对这些变化进行广泛详细的描述，我们旨在强调一些最重要的过程，并尽可能介绍这些过程背后的分子变化，并向读者推荐针对各个组成部分的深入、专业综述，以获取更多详细信息。
