Department of Chemistry, University of Reading, Whiteknights , Reading RG6 6AD, United Kingdom.
Chem Rev. 2017 Dec 27;117(24):14015-14041. doi: 10.1021/acs.chemrev.7b00522. Epub 2017 Dec 11.
This review is aimed to provide a concise yet extensive survey of key short bioactive peptide sequences for a range of applications ranging from biomaterials development to peptides with therapeutic uses. The following are considered: cell adhesion motifs, structural peptides, cell-penetrating and tumor-homing peptides, antimicrobial peptides, peptide hormones, growth factors and matrix metalloprotease substrates, neuropeptides, amyloid peptides, antioxidant peptides, peptide affinity tags, anticancer peptides, and others. This review provides a convenient resource, summarizing a broad range of important sequences with great utility as a resource concerning both small peptide drugs and also novel biofunctional peptide-based materials.
本文旨在对各种应用领域（从生物材料开发到治疗用途的肽）的关键短生物活性肽序列进行简明而广泛的综述。以下是一些考虑因素：细胞黏附基序、结构肽、细胞穿透肽和肿瘤归巢肽、抗菌肽、肽激素、生长因子和基质金属蛋白酶底物、神经肽、淀粉样肽、抗氧化肽、肽亲和标签、抗癌肽等。本文综述提供了一个方便的资源，总结了广泛的重要序列，这些序列具有作为小分子肽药物和新型基于生物功能肽材料的资源的巨大用途。
