Zhao Hua, Han Lixia, Chang David, Ye Yuanqing, Shen Jie, Daniel Carrie R, Gu Jian, Chow Wong-Ho, Wu Xifeng
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Oncotarget. 2017 Aug 3;8(57):96553-96567. doi: 10.18632/oncotarget.19903. eCollection 2017 Nov 14.
In the current study, we examined cross-sectional associations among social-demographics, lifestyle behaviors, and relative telomere length (RTL) in peripheral blood leukocytes, as well as longitudinal relationships among major chronic diseases, weight gain, and RTL, among 12,792 Mexican Americans aged 20 to 85 years in the Mano-A-Mano, the Mexican American Cohort. As expected, RTL was inversely correlated with age (=-0.15, <0.001). In the multivariate analysis, we found that RTL was positively correlated with levels of education (=0.021), self-insurance (=0.041), body mass index (BMI) (<0.001), and sleeping time per day ( for trend<0.001), and RTL was inversely correlated with sitting time per day ( for trend =0.001). In longitudinal analysis, we found that longer RTL was modestly but positively associated with increased risks of overall cancer (adjusted hazard ratio (adj.HR)=1.05, 95% conference interval (95%CI)=1.02-1.09). In quartile analysis, 4 quartile (longest RTL) was associated with 1.53-fold increased risk of overall cancer (adj.HR=1.53, 95%CI=1.11-2.10), compared to 1 quartile (shortest RTL). RTL was reversely associated with the risk of type-2 diabetes (adj.HR=0.89, 95%CI=0.82-0.94). In quartile analysis, 4 quartile (longest RTL) was associated with 48% decreased risk of typle-2 diabetes (adj.HR=0.52, 95%CI=0.32-0.70), compared to 1 quartile (shortest RTL). In addition, longer RTL was a positive predictor of at least 10% weight gain (adj.HR=1.03, 95%CI=1.00-1.05). In summary, our results in Mexican Americans support the notion that telomere length is a biological mechanism by which social demographics and health behaviors "get under the skin" to affect health.
在本研究中，我们调查了墨西哥裔美国人队列“手拉手”研究中12792名年龄在20至85岁的墨西哥裔美国人的社会人口统计学、生活方式行为与外周血白细胞相对端粒长度（RTL）之间的横断面关联，以及主要慢性病、体重增加和RTL之间的纵向关系。正如预期的那样，RTL与年龄呈负相关（=-0.15，<0.001）。在多变量分析中，我们发现RTL与教育水平（=0.021）、自我保险（=0.041）、体重指数（BMI）（<0.001）和每日睡眠时间（趋势<0.001）呈正相关，而RTL与每日久坐时间呈负相关（趋势=0.001）。在纵向分析中，我们发现较长的RTL与总体癌症风险增加呈适度但正相关（调整后的风险比（adj.HR）=1.05，95%置信区间（95%CI）=1.02-1.09）。在四分位数分析中，与第一四分位数（最短RTL）相比，第四四分位数（最长RTL）与总体癌症风险增加1.53倍相关（adj.HR=1.53，95%CI=1.11-2.10）。RTL与2型糖尿病风险呈负相关（adj.HR=0.89，95%CI=0.82-0.94）。在四分位数分析中，与第一四分位数（最短RTL）相比，第四四分位数（最长RTL）与2型糖尿病风险降低48%相关（adj.HR=0.52，95%CI=0.32-0.70）。此外，较长的RTL是体重至少增加10%的正向预测因子（adj.HR=1.03，95%CI=1.00-1.05）。总之，我们在墨西哥裔美国人中的研究结果支持以下观点：端粒长度是一种生物学机制，通过它社会人口统计学和健康行为“深入体内”影响健康。
