Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Cancer Epidemiol. 2019 Jun;60:1-7. doi: 10.1016/j.canep.2019.03.001. Epub 2019 Mar 14.
C-Reactive protein (CRP) is a well-known inflammatory marker, and elevated CRP levels has been reported to be associated with the risk of various cancers. To date, no study has investigated the association between elevated CRP and incidents of cancer among Mexican Americans. In the current prospective cohort study, we measured pre-diagnostic CRP levels in serum samples and evaluated their relationships with demographic characteristics and health behaviors associated with cancer risk among 2753 Mexican Americans selected from the Mano-A-Mano Mexican American Cohort Study. At baseline, median levels of serum CRP significantly differed by demographics (sex, age category, marital status, and education levels) and health behaviors (cigarette smoking status, alcohol drinking status, BMI category, and physical activity levels). In the multivariable analysis, the study participants who were women, older, never drinking alcohol, overweight or obese, and physically inactive had increased likelihood of having high CRP levels (≥ median levels among all study participants) compared to their counterparts. A total of 177 cancer cases were identified during the follow-up with a median follow-up time of 127 months. In the quartile analysis, study participants in the 4 quartile with highest CRP levels had significantly 1.88 fold increased risk of cancer (hazard ratio (HR) = 1.88, 95%CI: 1.12, 3.13) compared to those in the 1 quartile with lowest CRP levels. The association was further confirmed in analyses using clinical CRP levels. In summary, our findings suggested that serum CRP levels have potential to serve as a predictive marker of cancer risk in Mexican Americans.
C 反应蛋白（CRP）是一种众所周知的炎症标志物，已有研究报道 CRP 水平升高与多种癌症的风险相关。迄今为止，尚无研究调查 CRP 水平升高与墨西哥裔美国人癌症发病之间的关系。在目前这项前瞻性队列研究中，我们在血清样本中测量了 CRP 水平，并评估了其与癌症风险相关的人口统计学特征和健康行为之间的关系，这些特征和健康行为在从 Mano-A-Mano 墨西哥裔美国人队列研究中选择的 2753 名墨西哥裔美国人中进行了评估。在基线时，血清 CRP 水平的中位数因人口统计学特征（性别、年龄类别、婚姻状况和教育程度）和健康行为（吸烟状况、饮酒状况、BMI 类别和体力活动水平）而存在显著差异。在多变量分析中，与女性、年龄较大、从不饮酒、超重或肥胖以及不活跃的研究参与者相比，具有较高 CRP 水平（所有研究参与者中 CRP 水平中位数以上）的可能性更高。在随访期间共发现 177 例癌症病例，中位随访时间为 127 个月。在四分位分析中，CRP 水平最高的第 4 四分位组的研究参与者的癌症风险显著增加了 1.88 倍（危险比（HR）=1.88，95%置信区间：1.12，3.13），与 CRP 水平最低的第 1 四分位组相比。使用临床 CRP 水平进行的分析进一步证实了这种关联。总之，我们的研究结果表明，血清 CRP 水平可能成为墨西哥裔美国人癌症风险的预测标志物。
