Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sleep Health. 2019 Feb;5(1):78-83. doi: 10.1016/j.sleh.2018.09.004. Epub 2018 Oct 30.
To date, no study has investigated the association of sleep duration with cancer risk in Mexican Americans.
Using data from the Mano-A-Mano Mexican American Cohort study, we analyzed the relationship between sleep duration and overall cancer risk among Mexican Americans.
Of 10,802 subjects included in this study, 429 developed cancer during follow-up. Compared with study participants sleeping 8-9 hours per night, those sleeping less than 6 hours per night had significantly increased risk of overall cancer in both univariate and multivariate Cox regression analyses. After adjusting for social-demographic and lifestyle variables, sleeping less than 6 hours per night was associated with a 1.37-fold increased risk of overall cancer (hazard ratio = 1.37, 95% confidence interval: 1.01-1.97). In breast cancer alone, sleeping less than 6 hours per night was associated with a 1.86-fold increased risk of breast cancer (hazard ratio = 1.86, 95% confidence interval: 1.01-3.45) after adjustment for birthplace and language acculturation. In further stratified analysis, significant associations between sleeping less than 6 hours per night and overall cancer risk were evident among overweight participants, former drinkers, those with medium or high levels of physical activity, those married or living together, and those who had less than 2 hours of sitting time per day. In addition, increased cancer risk associated with long sleep duration (at least 9 hours per night) was observed among overweight participants and those with medium or high levels of physical activity.
Our results provide evidence to link sleep duration with cancer risk among Mexican Americans.
迄今为止，尚无研究调查墨西哥裔美国人的睡眠时间与癌症风险之间的关系。
使用来自“手牵手”墨西哥裔美国人队列研究的数据，我们分析了睡眠时间与墨西哥裔美国人整体癌症风险之间的关系。
在这项研究中，纳入了 10802 名受试者，其中 429 人在随访期间发生了癌症。与每晚睡眠 8-9 小时的研究参与者相比，每晚睡眠时间少于 6 小时的参与者在单变量和多变量 Cox 回归分析中均具有较高的整体癌症风险。在调整了社会人口统计学和生活方式变量后，每晚睡眠时间少于 6 小时与整体癌症风险增加 1.37 倍相关（风险比=1.37，95%置信区间：1.01-1.97）。仅在乳腺癌中，在调整出生地和语言融入度后，每晚睡眠时间少于 6 小时与乳腺癌风险增加 1.86 倍相关（风险比=1.86，95%置信区间：1.01-3.45）。在进一步的分层分析中，睡眠时间少于 6 小时与整体癌症风险之间存在显著关联，这种关联在超重参与者、前饮酒者、身体活动水平中等或较高的参与者、已婚或同居的参与者以及每天坐着时间少于 2 小时的参与者中更为明显。此外，在超重参与者和身体活动水平中等或较高的参与者中，长时间睡眠（每晚至少 9 小时）与癌症风险增加相关。
我们的研究结果提供了证据，表明睡眠时间与墨西哥裔美国人的癌症风险有关。
