Geldof A A, De Voogt H J, Rao B R
Department of Endocrinology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands.
Urol Res. 1989;17(1):9-12. doi: 10.1007/BF00261041.
We investigated the possibility that extracorporeal high energy shock wave (HESW) treatment of solid tumors increased metastatic tumor cell spread using a rapidly metastasising rat prostate tumor variant (R3327-MatLyLu). Volume of HESW treated primary tumor, the volume of metastatic lymph nodes and the number of lung tumor nodules formed were compared with values in untreated control rats. HESW treatment resulted in marked hemorrhage and readily visible hematoma at the focal point of treatment. Tumor histology directly after treatment showed extravascular blood cells due to breakage of blood vessels. Contrary to previous reports we could not observe a delay in tumor growth rate in either small or medium sized tumors. More importantly the extent of metastatic spread was not influenced by HESW treatment.
我们使用一种快速转移的大鼠前列腺肿瘤变体（R3327-MatLyLu），研究了实体瘤的体外高能冲击波（HESW）治疗增加转移性肿瘤细胞扩散的可能性。将接受HESW治疗的原发性肿瘤体积、转移性淋巴结体积和形成的肺肿瘤结节数量与未治疗的对照大鼠的值进行比较。HESW治疗在治疗焦点处导致明显出血和易于观察到的血肿。治疗后立即进行的肿瘤组织学检查显示，由于血管破裂，血管外有血细胞。与先前的报道相反，我们在小型或中型肿瘤中均未观察到肿瘤生长速率延迟。更重要的是，转移扩散的程度不受HESW治疗的影响。
