Ophthalmology Department, Weifang Traditional Chinese Hospital, 1055 Weizhou Road, Kuiwen District, Weifang 261000, China.
Otorhinolaryngological Department, Weifang Traditional Chinese Hospital, 1055 Weizhou Road, Kuiwen District, Weifang 261000, China.
Biomed Res Int. 2017;2017:4737064. doi: 10.1155/2017/4737064. Epub 2017 Nov 5.
Until now, the relationship of obstructive sleep apnoea (OSA) with diabetic retinopathy (DR) was controversial. This meta-analysis was performed to obtain definitive conclusion on this topic. Relevant articles were searched on databases of Pubmed, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI). The articles were selected according to inclusion and exclusion criteria. Odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the relationship of OSA with risk of DR. and value were used to assess the presence of heterogeneity. ≥ 50% or < 0.05 indicated significant heterogeneity. Sensitivity analysis was performed to evaluate the robustness of pooled results. Begg's funnel plot and Egger's regression analysis were adopted to assess publication bias. 6 eligible studies were selected in the present meta-analysis. The pooled results indicated that OSA was significantly associated with increased risk of DR (OR = 2.01, 95% CI = 1.49-2.72). Subgroup analysis based on type of diabetes mellitus suggested that OSA was related to DR in both Type 1 and Type 2 diabetes mellitus. Sensitivity analysis demonstrated that pooled results were robust. No significant publication bias was observed ( = 0.128). The results indicate that OSA is related to increased risk of DR.
到目前为止，阻塞性睡眠呼吸暂停（OSA）与糖尿病视网膜病变（DR）的关系仍存在争议。本荟萃分析旨在对这一主题得出明确的结论。在 Pubmed、Google Scholar 和中国国家知识基础设施（CNKI）数据库中搜索相关文章。根据纳入和排除标准选择文章。使用比值比（OR）及其 95%置信区间（CI）来评估 OSA 与 DR 风险的关系。 和 值用于评估异质性的存在。≥50%或<0.05 表示存在显著异质性。进行敏感性分析以评估汇总结果的稳健性。采用 Begg 漏斗图和 Egger 回归分析评估发表偏倚。本荟萃分析共纳入 6 项研究。汇总结果表明，OSA 与 DR 风险增加显著相关（OR=2.01，95%CI=1.49-2.72）。基于糖尿病类型的亚组分析表明，OSA 与 1 型和 2 型糖尿病均与 DR 相关。敏感性分析表明汇总结果稳健。未观察到显著的发表偏倚（ = 0.128）。结果表明，OSA 与 DR 风险增加相关。
