Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China.
Department of Radiation Oncology, Cancer Hospital of Fudan University, 270 Dong An Road, Shanghai, 200032, China.
Cancer Metastasis Rev. 2018 Mar;37(1):75-81. doi: 10.1007/s10555-017-9713-x.
Long non-coding RNA (lncRNA) genes have recently been discovered as key regulators of developmental, physiological, and pathological processes in humans. Recent studies indicate that lncRNAs regulate every step of gene expression, and their aberrant expression can be found in the majority of cancer types. Particularly, lncRNAs were found to function in tumor development and metastasis, which is the major cause of cancer-related death. Thus, exploring key roles of lncRNAs in metastasis is predicted to enhance our knowledge of metastasis, and uncover novel therapeutic targets and biomarkers of this process. In this review, we discuss the molecular mechanisms of lncRNAs in gene expression regulation and their function in metastasis.
长链非编码 RNA（lncRNA）基因最近被发现是人类发育、生理和病理过程的关键调节因子。最近的研究表明，lncRNAs 调节基因表达的每一个步骤，并且它们的异常表达可以在大多数癌症类型中找到。特别是，lncRNAs 被发现可以在肿瘤的发生和转移中发挥作用，这是癌症相关死亡的主要原因。因此，探索 lncRNAs 在转移中的关键作用，预计可以增强我们对转移的认识，并揭示该过程的新的治疗靶点和生物标志物。在这篇综述中，我们讨论了 lncRNAs 在基因表达调控中的分子机制及其在转移中的功能。
