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一名5个月大携带非O1/非O139产海地霍乱毒素的婴儿出现持续性腹泻。

Persistent diarrhoea in a 5-month-old baby carrying nonO1/nonO139 producing Haitian cholera toxin.

作者信息

Kumar P, Karmakar S, Prasad R, Chopra R, Khandelwal S, Gupta S, Dhariwal A C, Yadav P, Yadava P K

机构信息

National Centre for Disease Control, Delhi, India.

Aruna Asaf Ali Govt. Hospital, Delhi, India.

出版信息

New Microbes New Infect. 2017 Nov 28;21:72-74. doi: 10.1016/j.nmni.2017.10.008. eCollection 2018 Jan.

DOI:10.1016/j.nmni.2017.10.008
PMID:29234496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5721208/
Abstract

Cholera toxin (CT) is the principal virulence factor of for fatal cholera diarrhoea. Serogroups O1 and O139 harbour CT and are known to be epidemic strains. The remaining serogroups (nonO1/nonO139) are non-toxigenic and may be associated with mild disease. O1 serogroup emerged with a variant of CT known as Haitian cholera toxin (HCT). The HCT strains are hypervirulent and have been associated with severe cholera outbreaks in India, Western Africa and Haiti. Here, we report the presence of HCT () in a nonO1/nonO139 isolate causing persistent diarrhoea.

摘要

霍乱毒素（CT）是导致致命性霍乱腹泻的主要毒力因子。O1和O139血清群携带CT，已知为流行菌株。其余血清群（非O1/非O139）不产生毒素，可能与轻症疾病有关。O1血清群出现了一种名为海地霍乱毒素（HCT）的CT变体。HCT菌株具有高毒力，与印度、西非和海地的严重霍乱疫情有关。在此，我们报告在一株导致持续性腹泻的非O1/非O139分离株中存在HCT（）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33ad/5721208/5249112c407b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33ad/5721208/bcb04ca3c2c4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33ad/5721208/5249112c407b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33ad/5721208/bcb04ca3c2c4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33ad/5721208/5249112c407b/gr2.jpg

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Vibrio cholerae O1 Ogawa El Tor strains with the ctxB7 allele driving cholera outbreaks in south-western India in 2012.2012年在印度西南部引发霍乱疫情的携带ctxB7等位基因的霍乱弧菌O1小川型埃尔托菌株。
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