Mônaco-Ferreira Daniela Vicinansa, Leandro-Merhi Vânia Aparecida, Aranha Nilton César, Brandalise Andre, Brandalise Nelson Ary
Graduate Program in Health Sciences, Puc-Campinas, Campinas, SP, Brazil.
Graduate Program in Health Sciences and of the School of Nutrition, Puc-Campinas, Campinas, SP, Brazil.
Obes Surg. 2018 Jun;28(6):1636-1642. doi: 10.1007/s11695-017-3064-0.
The aim of this study was to investigate the lipid and glycemic profiles of patients up to 10 years after Roux-en-Y gastric bypass.
A retrospective, longitudinal study was conducted at a multidisciplinary center for the treatment of obesity in the state of São Paulo, Brazil. The study included 150 patients submitted to unbanded laparoscopic Roux-en-Y gastric bypass. The metabolic profile included total cholesterol and fractions, triglycerides, and fasting glucose. The patients were examined before and 3, 6, 12, 24, 48, 72, 96, and 120 months after surgery. Statistical analyses included the generalized estimating equations (GEE) and the Wilcoxon test at a significance level of 5%.
All postoperative fasting glucose, total cholesterol, and triglyceride (p < 0.0001) test results were significantly lower than the preoperative test results. Low-density lipoprotein cholesterol (LDL-c) differed significantly in all but the 120-month follow-up (p = 0.0129). High-density lipoprotein cholesterol (HDL-c) was significantly higher 12, 24, 48, and 72 months after surgery (p < 0.001) and also 120 months after surgery (p = 0.0002).
Gastric bypass promoted the control of metabolic diseases inherent to obesity as long as 10 years after surgery.
本研究旨在调查接受Roux-en-Y胃旁路手术长达10年的患者的血脂和血糖情况。
在巴西圣保罗州一家治疗肥胖症的多学科中心进行了一项回顾性纵向研究。该研究纳入了150例行无带腹腔镜Roux-en-Y胃旁路手术的患者。代谢指标包括总胆固醇及其组分、甘油三酯和空腹血糖。在手术前以及术后3、6、12、24、48、72、96和120个月对患者进行检查。统计分析包括广义估计方程（GEE）和Wilcoxon检验，显著性水平为5%。
所有术后空腹血糖、总胆固醇和甘油三酯（p < 0.0001）的检测结果均显著低于术前检测结果。除120个月随访外，低密度脂蛋白胆固醇（LDL-c）在所有随访中均有显著差异（p = 0.0129）。高密度脂蛋白胆固醇（HDL-c）在术后12、24、48和72个月显著升高（p < 0.001），在术后120个月也显著升高（p = 0.0002）。
胃旁路手术在术后长达10年的时间里都能促进对肥胖相关代谢疾病的控制。
