Barkhall Eirin Rosø, Tro Johanne, Sandvik Jorunn, Nymo Siren, Kulseng Bård, Johnsen Gjermund, Hoff Dag Arne Lihaug, Hole Torstein
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway.
Obesity Research Group, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway.
Obes Surg. 2025 Feb;35(2):441-449. doi: 10.1007/s11695-024-07601-x. Epub 2025 Jan 15.
Several studies have documented a beneficial short-term effect on lipid profile after Roux-en-Y gastric bypass (RYGB), but there is limited data on long-term changes.
To describe long-term (> 10 years) changes in lipid profile after RYGB and to explore the relationship of lipid changes to changes in weight and baseline and demographic parameters.
The BAROBS study is a prospective observational study post RYGB conducted at three different hospitals. Surgical procedures were performed between 2003 and 2009, and the collection of data was in 2018-2020. Data on lipid profile, weight, body mass index (BMI), percentage of total weight loss (%TWL), and pre- and postoperative type II diabetes mellitus (DMII) was collected at baseline, 1-2, 5, and 10 years post-surgery and was available for 314 of 546 patients in the study.
The mean (SD) follow-up was 11.5(± 1.5) years, with a mean reduction of 11.7% for LDL, 29.7% for TG, and 7.7% for total cholesterol compared to baseline. Except for HDL and total-/HDL-cholesterol-ratio, all lipid variables reached their greatest change after 1-2 years with an attenuation of changes at end of study. HDL and total-/HDL-cholesterol-ratio had stable values from 5 to 10 years post-surgery. Lipid profile improved more in patients with greater weight loss. There was a 59% reduction in DMII at end of study, and there was a significant relation between preoperative DMII and long-term lipid values.
There is an improvement of all lipid parameters after 10 years post RYGB related to both the magnitude of weight loss and the presence of DMII.
多项研究记录了Roux-en-Y胃旁路术（RYGB）后对血脂水平的短期有益影响，但关于长期变化的数据有限。
描述RYGB术后长期（>10年）血脂水平的变化，并探讨血脂变化与体重变化、基线及人口统计学参数之间的关系。
BAROBS研究是一项在三家不同医院进行的RYGB术后前瞻性观察研究。手术于2003年至2009年间进行，数据收集于2018年至2020年。在基线、术后1-2年、5年和10年收集血脂水平、体重、体重指数（BMI）、总体重减轻百分比（%TWL）以及术前和术后2型糖尿病（DMII）的数据，该研究中的546例患者中有314例可获得这些数据。
平均（标准差）随访时间为11.5（±1.5）年，与基线相比，低密度脂蛋白平均降低11.7%，甘油三酯降低29.7%，总胆固醇降低7.7%。除高密度脂蛋白和总胆固醇/高密度脂蛋白胆固醇比值外，所有血脂变量在术后1-2年变化最大，研究结束时变化减弱。高密度脂蛋白和总胆固醇/高密度脂蛋白胆固醇比值在术后5至10年保持稳定。体重减轻较多的患者血脂水平改善更明显。研究结束时DMII降低了59%，术前DMII与长期血脂值之间存在显著关系。
RYGB术后10年所有血脂参数均有改善，这与体重减轻幅度和DMII的存在有关。
