Turner-Stokes L, Jones M, Addison I, Mansell M, Isenberg D A
Bloomsbury Rheumatology Unit, University College, London.
Ann Rheum Dis. 1989 Jan;48(1):14-6. doi: 10.1136/ard.48.1.14.
It has been suggested again recently that the presence of rheumatoid factor (RF) in the serum of patients with systemic lupus erythematosus (SLE) protects them from the development of nephritis. In this study the RF is measured by standard latex test and by radioimmunoassay to detect IgM, IgA, and IgG isotypes, in patients with SLE with (26 patients) and without (25 patients) renal involvement, and in a control group of 21 patients with idiopathic renal disease. In addition, patients with SLE and nephritis were tested during active and inactive phases of their disease. No significant protective effect was observed from the presence of RF.
最近又有人提出，系统性红斑狼疮（SLE）患者血清中类风湿因子（RF）的存在可保护他们不发生肾炎。在本研究中，通过标准乳胶试验和放射免疫测定法检测RF，以检测IgM、IgA和IgG同种型，研究对象包括有肾脏受累的SLE患者（26例）、无肾脏受累的SLE患者（25例）以及21例特发性肾病患者组成的对照组。此外，对患有SLE和肾炎的患者在疾病的活动期和非活动期进行了检测。未观察到RF的存在有显著的保护作用。
