Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Holy Cross Centre, Calgary, AB, Canada.
Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada.
Br J Cancer. 2018 Feb 20;118(4):607-610. doi: 10.1038/bjc.2017.440. Epub 2017 Dec 12.
Evidence regarding the role of anthropometrics in prostate cancer survival is inconsistent. We examined the associations between anthropometric measures and survival outcomes.
Men diagnosed with prostate cancer (n=987) were recruited into a population-based case-control study between 1997 and 2000 then a prospective cohort study between 2000 and 2002 where anthropometric measurements (weight, height, body mass index, waist circumference, waist-hip ratio) were taken and participants were followed up to 19 years for survival outcomes. Cox proportional hazards were used to examine these associations.
Survival analyses suggested no clear pattern of associations between post-diagnosis anthropometric measurements and all-cause mortality, prostate-specific mortality, first recurrence/progression or new primary cancer.
We did not find a significant trend relating anthropometrics to survival outcomes after prostate cancer diagnosis. Continued assessment of objective measurements of body composition over the life-course is warranted to determine true associations between anthropometrics and survival after prostate cancer.
关于人体测量学在前列腺癌生存中的作用的证据不一致。我们研究了人体测量指标与生存结果之间的关系。
1997 年至 2000 年间，我们招募了 987 名被诊断患有前列腺癌的男性参加一项基于人群的病例对照研究，然后在 2000 年至 2002 年期间参加一项前瞻性队列研究，在此期间测量了人体测量指标（体重、身高、体重指数、腰围、腰臀比），并对参与者进行了长达 19 年的生存结果随访。使用 Cox 比例风险模型来检查这些关联。
生存分析表明，在诊断后，人体测量指标与全因死亡率、前列腺特异性死亡率、首次复发/进展或新发原发性癌症之间没有明显的关联模式。
我们没有发现与人体测量学与前列腺癌诊断后生存结果相关的显著趋势。在整个生命周期中，需要继续评估身体成分的客观测量，以确定人体测量学与前列腺癌后生存之间的真实关联。
