Yayla Muhammed, Halici Zekai, Kose Duygu, Tatar Arzu, Sitki Gozeler Mustafa
Department of Pharmacology, Kafkas University Faculty of Medicine Kars, Turkey.
Ear Nose Throat J. 2017 Dec;96(12):E14-E18. doi: 10.1177/014556131709601204.
Nasal polyposis (NP) is an inflammatory disease of the paranasal sinuses and nasal cavity. The primary purpose of our study is to determine the expression of 5-HT receptors both in nasal polyps and in healthy tissue in the nasal cavity. The subsequent aim is to compare the expression of 5-HT receptors in patients with NP and in inferior turbinate tissue (control). The study included 60 participants (40 with NP and 20 controls) aged 35 to 62 years. Nasal polyp samples were collected from all patients and relative 5-HT receptor expression analyses were performed. Reverse transcription polymerase chain reaction analysis of nasal polyps and control tissue identified 5-HT receptor expression in the nasal cavities of controls. This expression was approximately 67 times higher in nasal polyp tissue than in healthy tissue. Our study identifies the expression of 5-HT receptors in the nasal cavity for the first time and the first demonstration of increased 5-HT receptor expression in tissue from nasal polyps, which occur in the paranasal sinuses and nasal cavity.
鼻息肉病（NP）是一种鼻窦和鼻腔的炎症性疾病。我们研究的主要目的是确定5-羟色胺（5-HT）受体在鼻息肉以及鼻腔健康组织中的表达情况。后续目标是比较NP患者与下鼻甲组织（对照）中5-HT受体的表达。该研究纳入了60名年龄在35至62岁之间的参与者（40名NP患者和20名对照）。从所有患者处采集鼻息肉样本，并进行相关的5-HT受体表达分析。对鼻息肉和对照组织进行逆转录聚合酶链反应分析，确定了对照鼻腔中5-HT受体的表达。该表达在鼻息肉组织中比在健康组织中高约67倍。我们的研究首次确定了鼻腔中5-HT受体的表达，并且首次证明了在鼻窦和鼻腔中出现的鼻息肉组织中5-HT受体表达增加。
