高渗盐溶液预处理对缺血/再灌注损伤后肝功能改善的影响

Perconditioning associated to hypertonic saline solution on liver function improvement after ischemia/reperfusion injury.

作者信息

Ribeiro Rubens Fernando Gonçalves, Couteiro Rodrigo Paracampo, Monteiro Andrew Moraes, Rodrigues Ivone Aline da Silva, Cavalcante Lainy Carollyne da Costa, Gouveia Eduardo Henrique Herbster, Galvão Lucas Nascimento, Lopes Luiz Renato Oliveira, Yasojima Edson Yuzur, Brito Marcus Vinicius Henriques

机构信息

Fellow Master degree, Postgraduate Program in Surgery and Experimental Research, Universidade Estadual do Para (UEPA), Brazil. Statistical analysis, manuscript preparation, English language.

Graduate student, School of Medicine, UEPA, Belem-PA, Brazil. Care of animals, technical procedures, interpretation of data, manuscript preparation.

出版信息

Acta Cir Bras. 2017 Nov;32(11):949-955. doi: 10.1590/s0102-865020170110000006.

DOI:10.1590/s0102-865020170110000006

PMID:29236799

Abstract

PURPOSE

To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in liver ischemia/reperfusion injury in rats.

METHODS

25 male rats (Wistar) were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of liver ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during liver ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); Remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments.

RESULTS

Per+HSS group showed a lower degree of liver dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly improved liver function and reduced histological damage.