远程缺血预处理和盐酸曲马多对大鼠肾脏缺血/再灌注损伤中氧化应激的影响。
Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats.
作者信息
Oliveira Rita de Cássia Silva de, Brito Marcus Vinicius Henriques, Ribeiro Rubens Fernando Gonçalves, Oliveira Leonam Oliver Durval, Monteiro Andrew Moraes, Brandão Fernando Mateus Viegas, Cavalcante Lainy Carollyne da Costa, Gouveia Eduardo Henrique Herbster, Henriques Higor Yuri Bezerra
机构信息
PhD, Full Professor, Department of Pharmacology, Universidade Estadual do Pará (UEPA), Belem-PA, Brazil. Conception, design and scientific content of the study; critical revision.
PhD, Full Professor, Department of Experimental Surgery, UEPA, Belem-PA, Brazil. Conception, design and scientific content of the study; critical revision.
出版信息
Acta Cir Bras. 2017 Mar;32(3):229-235. doi: 10.1590/S0102-865020170030000007.
PURPOSE
: To evaluate the effects of tramadol hydrochloride associated to remote ischemic perconditioning on oxidative stress.
METHODS
: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Tramadol group (T) treated with tramadol hydrochloride (40mg/kg); remote ischemic perconditioning + Tramadol group (Per+T) with both treatments. Oxidative stress was assessed after 24 hours of reperfusion.
RESULTS
: Statistical differences were observed in MDA levels between I/R group with all groups (p<0.01), in addition there was difference between Tramadol with Sham, Per and Per+T groups (p<0.05), both in plasma and renal tissue.
CONCLUSION
: Remote ischemic perconditioning was more effective reducing renal ischemia-reperfusion injury than administration of tramadol or association of both treatments.
目的
评估盐酸曲马多联合远程缺血预处理对氧化应激的影响。
方法
25只雄性Wistar大鼠接受右肾切除术，并分为五组：假手术组（S）；缺血/再灌注组（I/R），肾缺血30分钟；远程缺血预处理组（Per），在肾脏缺血期间进行三个周期的10分钟缺血/再灌注；曲马多组（T），用盐酸曲马多（40mg/kg）治疗；远程缺血预处理+曲马多组（Per+T），接受两种治疗。再灌注24小时后评估氧化应激。
结果
I/R组与所有组之间的丙二醛（MDA）水平存在统计学差异（p<0.01），此外，曲马多组与假手术组、Per组和Per+T组之间在血浆和肾组织中均存在差异（p<0.05）。
结论
远程缺血预处理在减轻肾缺血-再灌注损伤方面比曲马多给药或两种治疗联合更有效。
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