Saykin A J, Gur R C, Sussman N M, O'Connor M J, Gur R E
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104.
Brain Cogn. 1989 Mar;9(2):191-200. doi: 10.1016/0278-2626(89)90029-8.
Laterality and age of onset effects on semantic and figural memory were evaluated in 30 right-handed, left speech dominant (amobarbital test) patients with epilepsy before and after temporal lobectomy. There were no effects of focus on WAIS-R IQ scores. Early onset (less than or equal to 5 years) was associated with lower IQ and memory (WMS). Left Temporal (LT) patients showed worse semantic than figural memory preoperatively. Unexpectedly, early onset LT had marked postoperative decline of figural memory, whereas late onset LT patients showed the previously reported worsening of semantic memory. Right Temporal (RT) lobectomy patients, in contrast, improved in both semantic and figural memory regardless of age of onset. A "crowding effect" was suggested by the decline in figural memory following surgery in the early onset LT patients who remained stable or improved in semantic memory. Results indicate the need to incorporate age of onset of seizures into laterality models of memory function following unilateral temporal-hippocampal resection.
在30例右利手、左侧言语优势（阿米妥试验）的癫痫患者接受颞叶切除术前后，评估了发作偏侧性和发病年龄对语义记忆和图形记忆的影响。病灶对韦氏成人智力量表修订版（WAIS-R）智商分数没有影响。早发性（小于或等于5岁）与较低的智商和记忆（韦氏记忆量表，WMS）相关。左侧颞叶（LT）患者术前语义记忆比图形记忆差。出乎意料的是，早发性LT患者术后图形记忆显著下降，而晚发性LT患者则出现了先前报道的语义记忆恶化。相比之下，右侧颞叶（RT）切除术患者无论发病年龄如何，语义记忆和图形记忆均有所改善。早发性LT患者术后图形记忆下降，而语义记忆保持稳定或改善，提示存在“拥挤效应”。结果表明，在单侧颞叶-海马切除术后的记忆功能偏侧性模型中，需要纳入癫痫发作的发病年龄。
