癌症治疗药物引起的皮肤问题对患者生活质量的影响：一项横断面研究。
The Impact of Skin Problems on the Quality of Life in Patients Treated with Anticancer Agents: A Cross-Sectional Study.
机构信息
Department of Dermatology, Seoul National University Hospital, Seoul, Korea.
Center for Skin Cancer and Adverse Skin Reaction to Chemotherapeutics, Seoul National University Cancer Hospital, Seoul, Korea.
出版信息
Cancer Res Treat. 2018 Oct;50(4):1186-1193. doi: 10.4143/crt.2017.435. Epub 2017 Dec 14.
PURPOSE
Patients treated with anticancer agents often experience a variety of treatment-related skin problems, which can impair their quality of life.
MATERIALS AND METHODS
In this cross-sectional study, Dermatology Life Quality Index (DLQI) and clinical information were evaluated in patients under active anticancer treatment using a questionnaire survey and their medical records review.
RESULTS
Of 375 evaluated subjects with anticancer therapy, 136 (36.27%) and 114 (30.40%) were treated for breast cancer and colorectal cancer, respectively. We found that women, breast cancer, targeted agent use, and longer duration of anticancer therapy were associated with higher dermatology-specific quality of life distraction. In addition, itching, dry skin, easy bruising, pigmentation, papulopustules on face, periungual inflammation, nail changes, and palmoplantar lesions were associated with significantly higher DLQI scores. Periungual inflammation and palmoplantar lesions scored the highest DLQI.
CONCLUSION
We believe our findings can be helpful to clinicians in counseling and managing the patients undergoing anticancer therapy.
目的
接受抗癌药物治疗的患者常经历多种与治疗相关的皮肤问题，这可能会降低其生活质量。
材料和方法
在这项横断面研究中，我们通过问卷调查和病历回顾评估了正在接受抗癌治疗的患者的皮肤病生活质量指数（Dermatology Life Quality Index，DLQI）和临床信息。
结果
在 375 名接受抗癌治疗的评估对象中，分别有 136 名（36.27%）和 114 名（30.40%）患者接受乳腺癌和结直肠癌治疗。我们发现，女性、乳腺癌、靶向药物治疗和抗癌治疗时间较长与更高的皮肤病特异性生活质量干扰相关。此外，瘙痒、皮肤干燥、容易瘀伤、色素沉着、面部丘疹脓疱、甲周炎症、指甲变化和掌跖皮损与更高的 DLQI 评分显著相关。甲周炎症和掌跖皮损的 DLQI 评分最高。
结论
我们认为，我们的研究结果可以帮助临床医生为接受抗癌治疗的患者提供咨询和管理。
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