Nguyen Sally, Perron Marjorie, Nadeau Sylvie, Odashiro Alexandre Nakao, Corriveau Marie-Noëlle
1 Laval University, Quebec City, QC, Canada.
2 CHU de Québec, Quebec City, QC, Canada.
Int J Surg Pathol. 2018 Jun;26(4):342-346. doi: 10.1177/1066896917747732. Epub 2017 Dec 13.
Epithelial myoepithelial carcinomas (EMCs) are rare low-grade salivary gland tumors. Here, we report the case of a 75-year-old man presenting with an oncocytic variant of EMC of the nasal cavity, initially diagnosed as an oncocytoma.
Our patient underwent functional sinus surgery in 2012. On pathology, an oncocytic neoplasm was found in the right nasal cavity, characterized by fragments of uniform bland oncocytic cells with bilayered arrangement of nuclei. Immunohistochemical stains demonstrated biphasic cells: luminal epithelial and basal cell-type myoepithelial cells. The tumor was best diagnosed as an oncocytoma. In 2015, the patient presented with a recurrent right inferior turbinate lesion, compatible with oncocytic EMC.
The patient underwent oncological surgery and received adjuvant radiotherapy. He had no disease recurrence.
Different variants of EMCs exist, such as oncocytic EMC. EMCs should be treated aggressively because they can be locally invasive, recur, and give rise to distant metastases.
上皮-肌上皮癌（EMC）是罕见的低度恶性涎腺肿瘤。在此，我们报告一例75岁男性鼻腔发生的嗜酸细胞型EMC病例，最初被诊断为嗜酸细胞瘤。
我们的患者于2012年接受了功能性鼻窦手术。病理检查发现右侧鼻腔有一个嗜酸细胞性肿瘤，其特征为均匀温和的嗜酸细胞碎片，细胞核呈双层排列。免疫组化染色显示双相细胞：腔面上皮细胞和基底细胞型肌上皮细胞。该肿瘤最初被诊断为嗜酸细胞瘤。2015年，患者右侧下鼻甲病变复发，符合嗜酸细胞型EMC。
患者接受了肿瘤手术并接受了辅助放疗。他没有疾病复发。
EMC存在不同的亚型，如嗜酸细胞型EMC。EMC应积极治疗，因为它们可能具有局部侵袭性、易复发并可发生远处转移。
