系统性红斑狼疮患者血浆可溶性髓系细胞触发受体-1水平的临床意义。

Clinical significance of plasma presepsin levels in patients with systemic lupus erythematosus.

作者信息

Tanimura Shun, Fujieda Yuichiro, Kono Michihiro, Shibata Yuhei, Hisada Ryo, Sugawara Eri, Nakamura Hiroyuki, Ohmura Kazumasa, Shimamura Sanae, Mitani Asako, Shida Haruki, Watanabe Toshiyuki, Kato Masaru, Oku Kenji, Bohgaki Toshiyuki, Amengual Olga, Yasuda Shinsuke, Shimizu Chikara, Atsumi Tatsuya

机构信息

a Department of Rheumatology, Endocrinology and Nephrology, Graduate School of Medicine and Faculty of Medicine , Hokkaido University , Sapporo , Japan.

b Division of Laboratory and Transfusion Medicine , Hokkaido University , Sapporo , Japan.

出版信息

Mod Rheumatol. 2018 Sep;28(5):865-871. doi: 10.1080/14397595.2017.1408755. Epub 2017 Dec 14.

DOI:10.1080/14397595.2017.1408755

PMID:29239264

Abstract

OBJECTIVES

Presepsin (PSEP: soluble CD14 subtype) is produced from bacteria-stimulated monocytes or neutrophils, thus recognized as a biomarker of sepsis. Aberrant functions in monocyte or neutrophils are increasingly recognized in systemic lupus erythematosus (SLE). We investigated whether plasma PSEP reflects disease activity in patients with SLE.

METHODS

This retrospective study comprised 35 patients with SLE and 72 with non-SLE autoimmune diseases who visited our facility during the period from August 2012 to September 2015. Plasma PSEP levels and laboratory data were compared between SLE and non-SLE. Clinical markers of SLE disease activity, including SLE disease activity index 2000 (SLEDAI-2K), serum complement concentrations and serum anti-ds-DNA antibodies were assessed in correlation with plasma PSEP levels.

RESULTS

Plasma PSEP levels in SLE were higher than those in non-SLE. This phenomenon holds true when comparing SLE and non-SLE patients in the absence of infection (p = .0008). Plasma PSEP levels in SLE patients negatively correlated with C3 (r = -0.4454, p = .0430), CH50 (r = -0.4502, p = .0406) and positively with SLEDAI-2K (r = 0.4801, p = .0237).

CONCLUSION

Elevated plasma PSEP levels were correlated with disease activity of SLE, suggesting inappropriate monocyte or neutrophil activation in the pathophysiology of SLE exacerbation.

摘要

目的

可溶性CD14亚型（Presepsin，PSEP）由细菌刺激的单核细胞或中性粒细胞产生，因此被认为是脓毒症的生物标志物。系统性红斑狼疮（SLE）中单核细胞或中性粒细胞的异常功能越来越受到认可。我们研究了血浆PSEP是否反映SLE患者的疾病活动度。

方法

这项回顾性研究纳入了2012年8月至2015年9月期间到我院就诊的35例SLE患者和72例非SLE自身免疫性疾病患者。比较SLE组和非SLE组的血浆PSEP水平及实验室数据。评估SLE疾病活动的临床指标，包括SLE疾病活动指数2000（SLEDAI-2K）、血清补体浓度和血清抗双链DNA抗体，并与血浆PSEP水平进行相关性分析。

结果

SLE患者的血浆PSEP水平高于非SLE患者。在无感染的SLE和非SLE患者之间比较时，这一现象依然存在（p = 0.0008）。SLE患者的血浆PSEP水平与C3呈负相关（r = -0.4454，p = 0.0430），与CH50呈负相关（r = -0.4502，p = 0.0406），与SLEDAI-2K呈正相关（r = 0.4801，p = 0.0237）。