Frecska E, Arato M, Banki C M, Mohari K, Perenyi A, Bagdy G, Fekete M I
National Institute of Nervous and Mental Diseases, Budapest.
Biol Psychiatry. 1989 Mar 15;25(6):692-6. doi: 10.1016/0006-3223(89)90239-4.
Ten unmedicated female inpatients with major depression (DSM-III) and 10 healthy volunteer women were given an intravenous injection of 0.1 mg fentanyl at 9:00 AM and 9:00 PM on different days. The prolactin secretory response to this opioid agonist was investigated for 1 h with serial blood sampling. Repeated measures Analysis of Variance yielded a significant effect of fentanyl administration on prolactin secretion (p less than 0.0001), and there were elevated hormone responses in the evening (p less than 0.005). No group difference was seen between healthy volunteers and depressed patients, but four of the depressives showed the most blunted response, and three of these low responders committed suicide within 1 year.
10名患有重度抑郁症（DSM-III）的未接受药物治疗的女性住院患者和10名健康志愿者女性在不同日期的上午9点和晚上9点接受了0.1毫克芬太尼的静脉注射。通过连续采血对这种阿片类激动剂的催乳素分泌反应进行了1小时的研究。重复测量方差分析显示芬太尼给药对催乳素分泌有显著影响（p小于0.0001），且晚上激素反应升高（p小于0.005）。健康志愿者和抑郁症患者之间未观察到组间差异，但有4名抑郁症患者表现出最迟钝的反应，其中3名低反应者在1年内自杀。
