Robertson A G, Jackman H, Meltzer H Y
Psychiatry Res. 1984 Apr;11(4):353-64. doi: 10.1016/0165-1781(84)90008-8.
The mean maximum prolactin response following administration of morphine sulfate, 5 mg, i.v., was significantly lower in 15 unmedicated inpatients with major depressive disorder than in 8 normal controls and 11 unmedicated inpatients with other psychiatric diagnoses. The maximum prolactin response of 8/15 depressed patients was less than the lowest response of any of the normal controls. Six of 15 depressed patients had blunted prolactin responses (less than 2 ng/ml) in the 60-minute sample. The diminished increase in serum prolactin after morphine in depressed patients may reflect anterior pituitary dysfunction or abnormalities in central endogenous opioid, dopamine, serotonin, or other neuroregulatory systems.
静脉注射5毫克硫酸吗啡后，15名未用药的重度抑郁症住院患者的平均最大催乳素反应显著低于8名正常对照者和11名未用药的患有其他精神疾病诊断的住院患者。15名抑郁症患者中有8名的最大催乳素反应低于任何一名正常对照者的最低反应。15名抑郁症患者中有6名在60分钟样本中的催乳素反应迟钝（低于2纳克/毫升）。抑郁症患者注射吗啡后血清催乳素增加减弱，可能反映了垂体前叶功能障碍或中枢内源性阿片、多巴胺、5-羟色胺或其他神经调节系统的异常。
