Judd L L, Risch S C, Parker D C, Janowsky D S, Segal D S, Huey L Y
Arch Gen Psychiatry. 1982 Dec;39(12):1413-6. doi: 10.1001/archpsyc.1982.04290120045009.
Prolactin concentrations of 30 unmedicated psychiatric inpatients and 11 normal controls were measured at baseline and at 30 and 60 minutes after the administration of 10 mg of intramuscular methadone hydrochloride. Methadone raised the prolactin level at 60 minutes to more than twice the mean baseline level for the full subject sample. Patients with depressive disorders had lower mean basal prolactin levels than did the other subjects, and also manifested attenuated prolactin responses to methadone. Eight of 16 depressives had markedly blunted prolactin responses, a finding consistent with other studies reporting deficient responses in depression. These data are consistent with the hypothesis that the pathophysiology of depressive disorders involves dysfunctions in the anterior pituitary itself or in the hypothalamic neurotransmitter and neuromodulator systems (eg, endorphins) that regulate the secretion of prolactin and other neurohormones.
在基线时以及肌肉注射10毫克盐酸美沙酮后30分钟和60分钟，测量了30名未接受药物治疗的精神科住院患者和11名正常对照者的催乳素浓度。美沙酮在60分钟时使催乳素水平升高至整个受试者样本平均基线水平的两倍以上。患有抑郁症的患者平均基础催乳素水平低于其他受试者，并且对美沙酮的催乳素反应也减弱。16名抑郁症患者中有8名的催乳素反应明显迟钝，这一发现与其他报道抑郁症反应不足的研究一致。这些数据与以下假设一致：抑郁症的病理生理学涉及垂体前叶本身或调节催乳素和其他神经激素分泌的下丘脑神经递质和神经调节系统（如内啡肽）功能障碍。
