Zis A P, Haskett R F, Albala A A, Carroll B J, Lohr N E
Biol Psychiatry. 1985 Mar;20(3):287-92. doi: 10.1016/0006-3223(85)90058-7.
Twenty-two unmedicated inpatients with major depression and 18 healthy volunteers of either sex were given an intravenous injection of 5 mg morphine. Blood samples were drawn immediately before and at intervals for 3 hrs after the injection and assayed for prolactin. Morphine stimulated prolactin secretion. The prolactin response of females was significantly greater than the response of male subjects. There were no significant differences in the prolactin response to morphine between depressed and healthy subjects. The implications of these findings for the hypothesized role of the opioid system in the pathophysiology of depression are discussed.
对22名未接受药物治疗的重度抑郁症住院患者和18名男女皆有的健康志愿者静脉注射5毫克吗啡。在注射前及注射后3小时内每隔一段时间采集血样，并检测催乳素水平。吗啡刺激了催乳素的分泌。女性的催乳素反应显著大于男性受试者的反应。抑郁症患者和健康受试者对吗啡的催乳素反应没有显著差异。讨论了这些发现对阿片系统在抑郁症病理生理学中假设作用的影响。
