评估进行性核上性麻痹和帕金森病的视网膜变化。
Evaluation of Retinal Changes in Progressive Supranuclear Palsy and Parkinson Disease.
机构信息
Departments of Ophthalmology (DGS, MU, CK, GEM) and Neurology (MG, MM), Faculty of Medicine, Erciyes University, Kayseri, Turkey.
出版信息
J Neuroophthalmol. 2018 Jun;38(2):151-155. doi: 10.1097/WNO.0000000000000591.
BACKGROUND
Differentiating Parkinson disease (PD) from progressive supranuclear palsy (PSP) can be challenging early in the clinical course. The aim of our study was to see if specific retinal changes could serve as a distinguishing feature.
METHODS
We used spectral domain optical coherence tomography (SD-OCT) with automatic segmentation to measure peripapillary nerve fiber layer thickness and the thickness and volume of retinal layers at the macula.
RESULTS
Thicknesses of superior peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell layer, inner plexiform layer, inner nuclear layer, and macular volume were more affected in PSP compared with PD (P < 0.05). Thicker inferotemporal pRNFL and lower macular volume were detected in levodopa users compared with nonusers in patients with PD.
CONCLUSIONS
PD and PSP are associated with distinct changes in retinal morphology, which can be assessed with SD-OCT.
背景
在疾病的早期阶段，将帕金森病（PD）与进行性核上性麻痹（PSP）区分开来具有一定挑战性。我们的研究旨在探讨特定的视网膜变化是否可以作为鉴别特征。
方法
我们使用频域光学相干断层扫描（SD-OCT）和自动分割技术来测量视盘周围神经纤维层厚度以及黄斑区视网膜各层的厚度和体积。
结果
与 PD 相比，PSP 患者的上方视盘周围视网膜神经纤维层（pRNFL）、黄斑神经节细胞层、内丛状层、内核层和黄斑体积厚度更受影响（P < 0.05）。PD 患者中，左旋多巴使用者的下方颞侧 pRNFL 较厚，黄斑体积较低，而非使用者则相反。
结论
PD 和 PSP 与视网膜形态的明显变化相关，这些变化可以通过 SD-OCT 进行评估。
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