De Bernardo Maddalena, Diana Francesco, Gioia Marco, De Luca Martina, Tepedino Maria Francesca, Pellecchia Maria Teresa, Rosa Nicola, Barone Paolo, Picillo Marina
Eye Unit, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84084 Fisciano, Italy.
Neuroradiology Unit, University Hospital San Giovanni di Dio e Ruggi d'Aragona, 84131 Salerno, Italy.
J Clin Med. 2023 Oct 22;12(20):6671. doi: 10.3390/jcm12206671.
Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease. Recently, several retinal layers in PSP compared to healthy controls. were found to be thinner. However, no studies evaluating the correlation between retinal layers and cerebral white matter changes, nor eventual choroidal changes in PSP, have been conducted so far. The goals of the present study were to explore potential differences in choroidal structure between PSP and healthy controls, and to describe the relationship between retinal layers' thickness and volume, using spectral-domain optical coherence tomography (SD-OCT) and age-related white matter change scores (ARWMC) using magnetic resonance imaging (MRI) of the brain. Choroidal structures of 26 PSP patients and 26 healthy controls using standard SD-OCT with an enhanced depth imaging (EDI) approach were analyzed; then, retinal the structures of 16 of these PSP patients using standard SD-OCT were examined; finally, the same patients underwent brain MRI, and their cerebral white matter changes were calculated. Non-statistically significant differences between PSP patients' and healthy controls' choroidal structure were found. On the contrary, PSP patients' inner retinal layers (INR), retinal pigmented epithelium (RPE) and all retinal layers' thicknesses in the macular region were found to be significantly correlated with ARWMC, independently from age and axial length (AL). PSP patients' neurological alterations go hand in hand with retinal ones, independently from age and axial length. Our results suggest a mutual relationship between cerebral and retinal structure pathological alterations. On the other hand, no significant differences in the choroidal evaluation compared to healthy controls have been found.
进行性核上性麻痹（PSP）是一种罕见的神经退行性疾病。最近，与健康对照相比，发现PSP患者的几个视网膜层变薄。然而，迄今为止，尚未有研究评估视网膜层与脑白质变化之间的相关性，也没有对PSP患者的脉络膜变化进行评估。本研究的目的是利用光谱域光学相干断层扫描（SD-OCT）探索PSP患者与健康对照之间脉络膜结构的潜在差异，并描述视网膜层厚度与体积之间的关系，同时利用脑部磁共振成像（MRI）评估年龄相关的白质变化评分（ARWMC）。采用增强深度成像（EDI）方法的标准SD-OCT对26例PSP患者和26例健康对照的脉络膜结构进行了分析；然后，对其中16例PSP患者采用标准SD-OCT检查了视网膜结构；最后，对同一批患者进行脑部MRI检查，并计算其脑白质变化情况。结果发现，PSP患者与健康对照的脉络膜结构之间无统计学显著差异。相反，发现PSP患者的视网膜内层（INR）、视网膜色素上皮（RPE）以及黄斑区所有视网膜层的厚度与ARWMC显著相关，且不受年龄和眼轴长度（AL）的影响。PSP患者的神经学改变与视网膜改变密切相关，且不受年龄和眼轴长度的影响。我们的结果提示脑结构与视网膜结构的病理改变之间存在相互关系。另一方面，与健康对照相比，在脉络膜评估方面未发现显著差异。
