Department of Cariology, Endodontology and Periodontology, University Medical Center Leipzig, Liebigstr. 10-14, 04103, Leipzig, Germany.
Department of General, Visceral and Pediatric Surgery, University Medical Center, Goettingen, Germany.
Clin Oral Investig. 2018 Jun;22(5):2039-2045. doi: 10.1007/s00784-017-2298-5. Epub 2017 Dec 14.
The aim of this study was to evaluate the oral health-related quality of life (OHRQoL) depending on dental and periodontal health of different patients before and after liver transplantation (pre- and postLTx) compared to a healthy control group (HC).
OHRQoL was rated using the German short form of Oral Health Impact Profile (OHIP G14). To estimate dental health, the decayed (D-T), missing (M-T), and filled (F-T) teeth index (DMF-T) was used. Periodontal health was classified as healthy/mild, moderate, or severe periodontitis. The following statistics are used: Mann-Whitney U test, Kruskal-Wallis test, chi-square test, and Fisher test (α = 5%).
A total of 24 preLTx, 47 postLTx, and 75 HC patients were included. Significant differences in DMF-T, D-T, M-T, and F-T scores were detected between groups (p < 0.001). Prevalence of periodontitis was comparable between groups (p = 0.340). OHRQoL was reduced in pre- and postLTx (OHIP G14 preLTx 4.2 [1.5; 0-4.0], postLTx 4.1 [1; 0-5.0], HC 1.4 [0; 0-2.0]; p = 0.003), without associations to their oral status (p > 0.05).
These preliminary findings show a reduced OHRQoL without associations to their oral status, which might indicate an influence of potential disease-related factors on OHRQoL. Further studies with larger groups are necessary to verify this observation.
A special dental care of patients before and after LTx is needed, including a comprehensive assessment of the individual patient's OHRQoL.
本研究旨在评估不同患者在肝移植前后(移植前和移植后)的口腔健康相关生活质量(OHRQoL),并与健康对照组(HC)进行比较。
使用德国口腔健康影响简表(OHIP G14)的短表评估 OHRQoL。为了评估牙齿健康,使用了龋齿(D-T)、缺失(M-T)和填充(F-T)牙齿指数(DMF-T)。牙周健康分为健康/轻度、中度或重度牙周炎。使用 Mann-Whitney U 检验、Kruskal-Wallis 检验、卡方检验和 Fisher 检验(α=5%)。
共纳入 24 例移植前、47 例移植后和 75 例 HC 患者。组间 DMF-T、D-T、M-T 和 F-T 评分存在显著差异(p<0.001)。组间牙周炎的患病率相似(p=0.340)。移植前和移植后 OHRQoL 均降低(OHIP G14 移植前 4.2[1.5;0-4.0],移植后 4.1[1;0-5.0],HC 1.4[0;0-2.0];p=0.003),与口腔状况无关(p>0.05)。
这些初步结果表明,OHRQoL 降低与口腔状况无关,这可能表明潜在疾病相关因素对 OHRQoL 的影响。需要进一步的大样本研究来验证这一观察结果。
肝移植前后患者需要特殊的口腔护理,包括对患者 OHRQoL 的全面评估。