College of Food Science, Southwest University, Tiansheng Road 2, Chongqing, 400715 PR China.
Food Funct. 2018 Jan 24;9(1):491-501. doi: 10.1039/c7fo01569k.
Self-aggregates of octenylsuccinate oat β-glucan (A) have been verified as nanocapsules to load curcumin, a representative of hydrophobic phytochemicals. This study primarily investigated the stability of curcumin-loaded As over food processing, storage and digestive fluids. Curcumin in As showed better stability over storage and thermal treatment than its free form. Curcumin loaded in A stored at 4 °C in the dark exhibited higher stability than that at higher temperatures or exposed to light. Approximately 18% of curcumin was lost after five freeze-thaw cycles. Curcumin in A was more stable than its free form in mimetic intestinal fluids, attesting to the effective protection of A for curcumin over digestive environments. When curcumin-loaded A travelled across mimetic gastric and intestinal fluids, curcumin was tightly accommodated in the capsule, while it rapidly escaped as the capsule reached the colon. Interestingly, the curcumin loaded in A generated higher values of C and area under the curve than did its free counterpart. These observations showed that A is a powerful vehicle for stabilizing hydrophobic phytochemicals in food processing and storage, facilitating their colon-targeted delivery and enhancing their bioavailability.
辛烯基琥珀酸燕麦 β-葡聚糖（A）的自聚集体已被证实为纳米胶囊，可负载姜黄素等疏水性植物化学物质。本研究主要考察了载姜黄素 A 在食品加工、储存和消化液中的稳定性。与游离形式相比，A 中负载的姜黄素在储存和热处理过程中更稳定。在 4°C 避光储存的 A 中负载的姜黄素比在较高温度或暴露于光线下的姜黄素更稳定。经过五次冻融循环后，约有 18%的姜黄素损失。在模拟肠道液中，A 中负载的姜黄素比游离形式更稳定，这证明了 A 对姜黄素在消化环境中的有效保护。当载有姜黄素的 A 穿越模拟胃和肠道液时，姜黄素被紧密容纳在胶囊中，而当胶囊到达结肠时，姜黄素迅速逸出。有趣的是，载有姜黄素的 A 产生的 C 值和曲线下面积均高于游离姜黄素。这些观察结果表明，A 是一种在食品加工和储存过程中稳定疏水性植物化学物质的有效载体，有助于其在结肠中的靶向递送，并提高其生物利用度。
