Atasoy Selen, Roseman Leor, Kaelen Mendel, Kringelbach Morten L, Deco Gustavo, Carhart-Harris Robin L
Center of Brain and Cognition, Computational Neuroscience Group, Universitat Pompeu Fabra, Barcelona, Spain.
Psychedelic Research Group, Psychopharmacology Unit, Centre for Psychiatry, Department of Medicine, Imperial College London, London, UK.
Sci Rep. 2017 Dec 15;7(1):17661. doi: 10.1038/s41598-017-17546-0.
Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used 'connectome-harmonic decomposition', a novel method to investigate the dynamical changes in brain states. We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the non-random increase in co-activation across frequencies. Interestingly, the frequency distribution of the active repertoire of brain states under LSD closely follows power-laws indicating a re-organization of the dynamics at the edge of criticality. Beyond the present findings, these methods open up for a better understanding of the complex brain dynamics in health and disease.
最近的研究已开始阐明麦角酸二乙酰胺（LSD）对人脑的影响，但其潜在动态尚未完全被理解。在此，我们使用了“连接组谐波分解”这一新颖方法来研究脑状态的动态变化。我们发现，LSD以频率选择性的方式改变个体谐波脑状态的能量和功率。值得注意的是，这导致了活跃脑状态集合的扩展，鉴于跨频率共激活的非随机增加，这暗示着脑动态的全面重组。有趣的是，LSD作用下活跃脑状态集合的频率分布紧密遵循幂律，表明在临界边缘的动态重组。除了目前的研究结果，这些方法为更好地理解健康和疾病中的复杂脑动态开辟了道路。
