Song Hang, Liu Bin, Dong Bin, Xu Jing, Zhou Hui, Na Sha, Liu Yanyan, Pan Yunxia, Chen Fengyuan, Li Lu, Wang Jinghui
Department of Biochemistry and Molecular Biology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China.
Institute of Integrated Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei, China.
Front Cell Dev Biol. 2021 Mar 2;9:650426. doi: 10.3389/fcell.2021.650426. eCollection 2021.
A rapidly growing research evidence has begun to shed light on the potential application of exosome, which modulates intercellular communications. As donor cell released vesicles, exosomes could play roles as a regulator of cellular behaviors in up-taken cells, as well as a delivery carrier of drugs for targeted cells. Natural product is an invaluable drug resources and it is used widely as therapeutic agents in cancers. This review summarizes the most recent advances in exosomes as natural product delivery carriers in cancer therapy from the following aspects: composition of exosomes, biogenesis of exosomes, and its functions in cancers. The main focus is the advantages and applications of exosomes for drug delivery in cancer therapy. This review also summarizes the isolation and application of exosomes as delivery carriers of natural products in cancer therapy. The recent progress and challenges of using exosomes as drug delivery vehicles for five representative anti-cancer natural products including paclitaxel, curcumin, doxorubicin, celastrol, and β-Elemene. Based on the discussion on the current knowledge about exosomes as delivery vehicles for drugs and natural compounds to the targeted site, this review delineates the landscape of the recent research, challenges, trends and prospects in exosomes as delivery vehicles for drugs and natural compounds for cancer treatment.
越来越多的研究证据开始揭示外泌体的潜在应用，外泌体可调节细胞间通讯。作为供体细胞释放的囊泡，外泌体可作为摄取细胞中细胞行为的调节剂，以及靶向细胞的药物递送载体。天然产物是一种宝贵的药物资源，在癌症治疗中被广泛用作治疗剂。本文综述了外泌体作为天然产物递送载体在癌症治疗中的最新进展，包括外泌体的组成、生物发生及其在癌症中的功能。主要关注外泌体在癌症治疗中药物递送的优势和应用。本文还总结了外泌体作为天然产物递送载体在癌症治疗中的分离和应用。使用外泌体作为包括紫杉醇、姜黄素、阿霉素、雷公藤红素和β-榄香烯在内的五种代表性抗癌天然产物的药物递送载体的最新进展和挑战。基于对外泌体作为药物和天然化合物递送载体将其递送至靶位点的现有知识的讨论，本文描绘了外泌体作为癌症治疗药物和天然化合物递送载体的最新研究、挑战、趋势和前景。
