Department of Community Health, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chia-Yi City, Taiwan.
School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan.
J Sci Food Agric. 2020 Apr;100(6):2380-2388. doi: 10.1002/jsfa.10246. Epub 2020 Feb 9.
An imbalanced fat or excess energy intake always results in obesity and increased serum/liver lipids, thus leading to metabolic syndromes. Given the bioactive components in black vinegar (BV), such as branched amino acids, phenolic profile, and mineral contents, we investigated the antiobesity effects of BV-based supplements in rats fed a high-fat diet (HFD).
HFD (30% fat, w/w) feeding increased (P < 0.05) body weight, weight gains, weights of livers and mesenteric, epididymal, and perirenal adipose tissues, and serum/liver triglyceride levels relative to those of rats fed a normal diet (4% fat, w/w; CON). These increased values were ameliorated (P < 0.05) by supplementing with BV-based supplements but were still higher (P < 0.05) than those of CON rats. The increased areas of perirenal adipocytes in rats fed with an HFD were also decreased (P < 0.05) by supplementing with BV-based supplements, which might result from an upregulation (P < 0.05) of 5'-adenosine monophosphate-activated protein kinase (AMPK), carnitine palmitoyltransferase-1 (CPT1), and uncoupling protein-2 (UCP2) in the perirenal adipose tissues. A similar effect was observed for AMPK, peroxisome proliferator-activated receptor alpha, retinoid X receptor alpha, CPT1, and UCP2 gene and protein levels in livers (P < 0.05). Generally, BV-based supplements increased the fecal triglyceride, cholesterol, and bile acid levels of rats fed with an HFD, which partially contribute to the lipid-lowering effects. Furthermore, BV-based supplements increased (P < 0.05) hepatic Trolox equivalent antioxidant capacity and lowered (P < 0.05) serum/liver thiobarbituric acid reactive substances values in HFD-fed rats.
In a chronic high-fat dietary habit, the food-grade BV-based supplement is a good daily choice to ameliorate obesity and its associated comorbidities. © 2020 Society of Chemical Industry.
脂肪或能量摄入不平衡总是导致肥胖和血清/肝脏脂质增加，从而导致代谢综合征。鉴于黑醋（BV）中的生物活性成分，如支链氨基酸、酚类谱和矿物质含量，我们研究了基于 BV 的补充剂对高脂肪饮食（HFD）喂养大鼠的抗肥胖作用。
HFD（30%脂肪，w/w）喂养增加（P < 0.05）体重、体重增加、肝脏和肠系膜、附睾和肾周脂肪组织的重量以及血清/肝脏甘油三酯水平与正常饮食（4%脂肪，w/w；CON）喂养的大鼠相比。BV 基补充剂的补充改善了这些增加的值（P < 0.05），但仍高于 CON 大鼠（P < 0.05）。HFD 喂养大鼠肾周脂肪细胞面积的增加也通过补充 BV 基补充剂而减少（P < 0.05），这可能是由于肾周脂肪组织中 5'-腺苷一磷酸激活蛋白激酶（AMPK）、肉碱棕榈酰转移酶-1（CPT1）和解偶联蛋白-2（UCP2）的上调（P < 0.05）所致。在肝脏中也观察到类似的 AMPK、过氧化物酶体增殖物激活受体-α、视黄醇 X 受体-α、CPT1 和 UCP2 基因和蛋白水平的效果（P < 0.05）。一般来说，BV 基补充剂增加了 HFD 喂养大鼠的粪便甘油三酯、胆固醇和胆汁酸水平，这部分有助于降低血脂。此外，BV 基补充剂增加了 HFD 喂养大鼠肝脏 Trolox 当量抗氧化能力（P < 0.05），降低了血清/肝脏硫代巴比妥酸反应物值（P < 0.05）。
在慢性高脂肪饮食习惯中，食品级 BV 基补充剂是改善肥胖及其相关并发症的良好日常选择。© 2020 化学工业协会。
