核长非编码 RNA：基因表达的关键调控因子。
Nuclear Long Noncoding RNAs: Key Regulators of Gene Expression.
机构信息
Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, 601 S Goodwin Avenue, Urbana, IL 61801, USA; These authors contributing equally.
Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, 601 S Goodwin Avenue, Urbana, IL 61801, USA.
出版信息
Trends Genet. 2018 Feb;34(2):142-157. doi: 10.1016/j.tig.2017.11.005. Epub 2018 Feb 7.
Abstract
A significant portion of the human genome encodes genes that transcribe long nonprotein-coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched on the chromatin or localized to specific subnuclear compartments. Nuclear lncRNAs participate in several biological processes, including chromatin organization, and transcriptional and post-transcriptional gene expression, and also act as structural scaffolds of nuclear domains. Here, we highlight recent studies demonstrating the role of lncRNAs in regulating gene expression and nuclear organization in mammalian cells. In addition, we update current knowledge about the involvement of the most-abundant and conserved lncRNA, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), in gene expression control.
摘要
人类基因组的很大一部分编码转录长非蛋白编码 RNA（lncRNA）的基因。大量的 lncRNA 定位于细胞核内，要么富集在染色质上，要么定位于特定的亚核区室。核 lncRNA 参与多种生物学过程，包括染色质组织、转录和转录后基因表达，并作为核域的结构支架。在这里，我们强调了最近的研究表明 lncRNA 在调节哺乳动物细胞中的基因表达和核组织中的作用。此外，我们更新了目前关于最丰富和最保守的 lncRNA-转移相关肺腺癌转录物 1（MALAT1）在基因表达控制中的参与的知识。
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