State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of the Chinese Academy of Sciences, CAS, Shanghai 200031, China.
State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of the Chinese Academy of Sciences, CAS, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Trends Biochem Sci. 2020 Nov;45(11):947-960. doi: 10.1016/j.tibs.2020.07.001. Epub 2020 Aug 13.
Long noncoding RNAs (lncRNAs) are crucial regulators in diverse cellular contexts and biological processes. The subcellular localization of lncRNAs determines their modes of action. Compared to mRNAs, however, many mRNA-like lncRNAs are preferentially localized to the nucleus where they regulate chromatin organization, transcription, and different nuclear condensates. Recent studies have revealed the complex mechanisms that govern lncRNA nuclear retention. We review current understanding of how the transcription and processing of lncRNAs, motifs within lncRNAs, and trans-factors coordinately contribute to their nuclear retention in mammalian cells.
长链非编码 RNA（lncRNA）是多种细胞环境和生物过程中的关键调节因子。lncRNA 的亚细胞定位决定了它们的作用模式。然而，与 mRNA 相比，许多类似 mRNA 的 lncRNA 优先定位于细胞核，在细胞核中它们调节染色质组织、转录和不同的核凝聚物。最近的研究揭示了调控 lncRNA 核保留的复杂机制。我们综述了目前对于 lncRNA 的转录和加工、lncRNA 内的基序以及转因子如何协同作用以将其保留在哺乳动物细胞中的核内的理解。
