利用生物材料改进疫苗和免疫疗法设计。
Improving Vaccine and Immunotherapy Design Using Biomaterials.
机构信息
Fischell Department of Bioengineering, University of Maryland, 8228 Paint Branch Drive, College Park, MD 20742, USA.
Department of Surgery, University of Maryland School of Medicine, 29 South Greene Street, Baltimore, MD 21201, USA; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, MD 21201, USA; Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA; Marlene and Stewart Greenebaum Cancer Center, 22 South Greene Street, Baltimore, MD 21201, USA.
出版信息
Trends Immunol. 2018 Feb;39(2):135-150. doi: 10.1016/j.it.2017.10.002. Epub 2017 Dec 14.
Abstract
Polymers, lipids, scaffolds, microneedles, and other biomaterials are rapidly emerging as technologies to improve the efficacy of vaccines against infectious disease and immunotherapies for cancer, autoimmunity, and transplantation. New studies are also providing insight into the interactions between these materials and the immune system. This insight can be exploited for more efficient design of vaccines and immunotherapies. Here, we describe recent advances made possible through the unique features of biomaterials, as well as the important questions for further study.
摘要
聚合物、脂质、支架、微针和其他生物材料作为技术正在迅速涌现，以提高针对传染病的疫苗和癌症、自身免疫和移植的免疫疗法的疗效。新的研究也为这些材料与免疫系统之间的相互作用提供了深入了解。这种见解可以被利用来更有效地设计疫苗和免疫疗法。在这里，我们描述了通过生物材料的独特特性实现的最新进展，以及进一步研究的重要问题。
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