Department of Pharmacy, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan 030012, China.
Department of Endocrinology, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan 030012, China.
J Immunol Res. 2017;2017:3780572. doi: 10.1155/2017/3780572. Epub 2017 Nov 8.
To investigate the correlation between the clinical effects of Huangqi () on different stages of diabetic nephropathy (DN) and the pharmacological effect of Huangqi on the activity of inducible nitric oxide synthase (iNOS) in macrophages in different states.
The PubMed, China National Knowledge Infrastructure, and Wanfang databases were searched. Clinical data was sourced from papers on treatment of different stages of DN with Huangqi, and pharmacological data was from papers on the effects of Huangqi on the iNOS activity of macrophages in a resting or an activated state.
Meta-analysis of Huangqi injections on stages III and III-IV DN and randomized controlled trials on other stages showed that Huangqi had therapeutic effects on different stages of DN and on macrophages in different states: inducing normal macrophages in a resting state to generate nitric oxide (NO), tumor necrosis factor-, and so forth upon iNOS activation; inhibiting NO generation by normal lipopolysaccharide- (LPS-) activated macrophages; and enhancing NO generation by LPS-induced macrophages from patients with renal failure.
Huangqi can regulate iNOS activity of macrophages in different states . These biphasic or antagonistic effects may explain why Huangqi can be used to treat different stages of DN.
探讨黄芪在不同糖尿病肾病（DN）阶段的临床疗效与黄芪对不同状态下巨噬细胞诱导型一氧化氮合酶（iNOS）活性的药理作用之间的相关性。
检索PubMed、中国知网和万方数据库。临床数据来源于黄芪治疗不同阶段 DN 的文献，药理数据来源于黄芪对静息或激活状态下巨噬细胞 iNOS 活性影响的文献。
对黄芪注射液治疗 III 期和 III-IV 期 DN 的荟萃分析以及对其他阶段的随机对照试验表明，黄芪对不同阶段的 DN 和不同状态的巨噬细胞具有治疗作用：诱导静息状态下的正常巨噬细胞在 iNOS 激活时产生一氧化氮（NO）、肿瘤坏死因子等；抑制正常脂多糖（LPS）激活的巨噬细胞产生 NO；增强肾衰竭患者 LPS 诱导的巨噬细胞产生 NO。
黄芪可以调节不同状态下巨噬细胞的 iNOS 活性。这些双相或拮抗作用可能解释了为什么黄芪可用于治疗不同阶段的 DN。
