Wang Hanfei, Zhao Hengji, Tai Bocheng, Wang Simeng, Ihsan Awais, Hao Haihong, Cheng Guyue, Tao Yanfei, Wang Xu
National Reference Laboratory of Veterinary Drug Residues (HZAU), Veterinary Medicine Research Center, Huazhong Agricultural University, Wuhan 430070, China.
Department of Biosciences, COMSATS University Islamabad, Sahiwal 44000, Pakistan.
Vet Sci. 2024 Dec 21;11(12):672. doi: 10.3390/vetsci11120672.
The widespread utilization of antibiotic growth promoters (AGPs) boosts the growth rate of food animals and enhances human living standards. Nevertheless, it is accompanied by escalating antibiotic resistance. Consequently, there is an urgent demand to develop novel alternatives to growth promoters. The objective of this study was to develop a non-antibiotic growth promoter (NAGP) for augmenting the growth rate of food animals. The growth-promoting effect of plant-derived NAGPs was assessed in mice and broiler chickens, and its growth-promoting mechanism was initially investigated. The results reveal that a combination of hawthorn (also known as shanzha) and astragalus (also known as huangqi) extracts (SQ) enhanced the growth rate of mice both and , attributed to their significant capacity to promote muscle growth and improve immunity ( < 0.05). The composite super energy extract M (CSEE-M), further optimized on the basis of SQ, significantly improved growth performance and feed conversion ratio, and elevated the activity of intestinal digestive enzymes ( < 0.05) in both mice and broilers and reshaped the gut microbiota of broilers. The addition of 0.5% CSEE-M to broiler drinking water significantly increased muscle content and improved carcass quality ( < 0.05). In conclusion, both SQ and CSEE-M hold great promise as NAGPs and serve as effective substitutes to AGPs. This research not only furnishes new solutions for the misuse of antibiotics but presents a fresh perspective for the development of growth promoters.
抗生素生长促进剂（AGPs）的广泛使用提高了食用动物的生长速度，提升了人类生活水平。然而，这伴随着抗生素耐药性的不断上升。因此，迫切需要开发新型生长促进剂替代品。本研究的目的是开发一种用于提高食用动物生长速度的非抗生素生长促进剂（NAGP）。在小鼠和肉鸡中评估了植物源NAGPs的生长促进作用，并初步研究了其生长促进机制。结果表明，山楂（又称山楂）和黄芪（又称黄芪）提取物的组合（SQ）在第[具体时间1]和第[具体时间2]均提高了小鼠的生长速度，这归因于它们显著的促进肌肉生长和提高免疫力的能力（P<0.05）。在SQ的基础上进一步优化的复合超级能量提取物M（CSEE-M），显著改善了小鼠和肉鸡的生长性能和饲料转化率，并提高了肠道消化酶的活性（P<0.05），还重塑了肉鸡的肠道微生物群。在肉鸡饮用水中添加0.5%的CSEE-M显著增加了肌肉含量并改善了胴体品质（P<0.05）。总之，SQ和CSEE-M作为NAGPs都具有很大的潜力，可作为AGPs的有效替代品。本研究不仅为抗生素的滥用提供了新的解决方案，也为生长促进剂的开发提供了新的视角。
