Cercelaru Liliana, Stepan Alex Emilian, Mărgăritescu Claudiu, Osman Andrei, Popa Ionelia Carmen, Florescu Mirela Marinela, Simionescu Cristiana Eugenia, Mărgăritescu Otilia Clara
Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania;
Rom J Morphol Embryol. 2017;58(3):761-766.
E-cadherin, β-catenin and Snail are important molecules involved in cellular adhesion and epithelial-mesenchymal transition. Loss of E-cadherin expression, nuclear relocation of β-catenin and high expression of Snail are connected to tumor progression, rapid cell growth and metastasis. The aim of our study was to analyze the immunohistochemical expression of β-catenin, E-cadherin and Snail, depending on clinico-morphological aspects of the laryngeal squamous cell carcinomas. Our results revealed variable E-cadherin, β-catenin and Snail expression, depending on differentiation degree and tumor stage. These markers can be helpful in identifying the aggressive laryngeal squamous carcinomas.
E-钙黏蛋白、β-连环蛋白和蜗牛蛋白是参与细胞黏附及上皮-间质转化的重要分子。E-钙黏蛋白表达缺失、β-连环蛋白核转位以及蜗牛蛋白高表达与肿瘤进展、细胞快速生长和转移相关。我们研究的目的是根据喉鳞状细胞癌的临床形态学特征，分析β-连环蛋白、E-钙黏蛋白和蜗牛蛋白的免疫组化表达情况。我们的结果显示，E-钙黏蛋白、β-连环蛋白和蜗牛蛋白的表达因分化程度和肿瘤分期而异。这些标志物有助于识别侵袭性喉鳞状癌。
