Department of Material Science, École Polytechnique Fédérale de Lausanne (EPFL). MXG 030, Station 12, 1015, Lausanne, Switzerland.
Chem Rec. 2018 Jul;18(7-8):819-828. doi: 10.1002/tcr.201700065. Epub 2017 Dec 18.
Monolayer protected gold nanoparticles (AuNPs) have a huge potential for the development of innovative sensing systems for the detection of metal ions and small molecules. The organic ligand shell, primarily utilized to stabilize the gold core, can be rationally designed to promote selective interactions with a desired analyte. In addition, the outstanding physical and optical properties of AuNPs can be exploited to obtain analytically useful signals upon analyte binding. In this account, we review recent advances in AuNP-based sensing systems emphasizing on the rational design of the ligand shell for detection of heavy metal ions and small molecules. We examine various strategies of detection by evaluating their improvements in terms of sensitivity, selectivity and applicability to real samples.
单层保护金纳米粒子（AuNPs）在开发用于检测金属离子和小分子的创新传感系统方面具有巨大的潜力。有机配体壳主要用于稳定金核，可以进行合理设计以促进与所需分析物的选择性相互作用。此外，可以利用 AuNPs 的出色物理和光学特性在分析物结合时获得具有分析价值的信号。在本报告中，我们重点介绍了配体壳的合理设计，以用于检测重金属离子和小分子，综述了基于 AuNP 的传感系统的最新进展。我们通过评估其在灵敏度、选择性和对实际样品的适用性方面的改进，检查了各种检测策略。
