正常人血清免疫球蛋白M对杜氏利什曼原虫前鞭毛体凝集、补体介导杀伤及人单核细胞吞噬作用的影响
Effect of immunoglobulin M from normal human serum on Leishmania donovani promastigote agglutination, complement-mediated killing, and phagocytosis by human monocytes.
作者信息
Navin T R, Krug E C, Pearson R D
机构信息
Department of Medicine, University of Virginia School of Medicine, Charlottesville 22908.
出版信息
Infect Immun. 1989 Apr;57(4):1343-6. doi: 10.1128/iai.57.4.1343-1346.1989.
Abstract
Serum from healthy, nonimmune humans contained immunoglobulin M (IgM) antibodies that agglutinated Leishmania donovani promastigotes, activated complement, and enhanced promastigote ingestion by human monocytes. The findings indicate that IgM antibodies have the capacity to affect the initial interaction of L. donovani promastigotes with human host defenses.
摘要
来自健康、未免疫人群的血清中含有免疫球蛋白M（IgM）抗体，这些抗体可凝集杜氏利什曼原虫前鞭毛体、激活补体，并增强人单核细胞对前鞭毛体的摄取。这些发现表明，IgM抗体有能力影响杜氏利什曼原虫前鞭毛体与人类宿主防御的初始相互作用。
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