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正常人血清免疫球蛋白M对杜氏利什曼原虫前鞭毛体凝集、补体介导杀伤及人单核细胞吞噬作用的影响

Effect of immunoglobulin M from normal human serum on Leishmania donovani promastigote agglutination, complement-mediated killing, and phagocytosis by human monocytes.

作者信息

Navin T R, Krug E C, Pearson R D

机构信息

Department of Medicine, University of Virginia School of Medicine, Charlottesville 22908.

出版信息

Infect Immun. 1989 Apr;57(4):1343-6. doi: 10.1128/iai.57.4.1343-1346.1989.

DOI:10.1128/iai.57.4.1343-1346.1989
PMID:2925255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC313275/
Abstract

Serum from healthy, nonimmune humans contained immunoglobulin M (IgM) antibodies that agglutinated Leishmania donovani promastigotes, activated complement, and enhanced promastigote ingestion by human monocytes. The findings indicate that IgM antibodies have the capacity to affect the initial interaction of L. donovani promastigotes with human host defenses.

摘要

来自健康、未免疫人群的血清中含有免疫球蛋白M（IgM）抗体，这些抗体可凝集杜氏利什曼原虫前鞭毛体、激活补体，并增强人单核细胞对前鞭毛体的摄取。这些发现表明，IgM抗体有能力影响杜氏利什曼原虫前鞭毛体与人类宿主防御的初始相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33b0/313275/072c58f04c20/iai00064-0347-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33b0/313275/072c58f04c20/iai00064-0347-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33b0/313275/072c58f04c20/iai00064-0347-a.jpg

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本文引用的文献

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Mechanism of lethal effect of human serum upon Leishmania donovani.人血清对杜氏利什曼原虫致死作用的机制
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Antileishmanial activity of chlorpromazine.氯丙嗪的抗利什曼原虫活性。
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Differential survival of Leishmania donovani amastigotes in human monocytes.杜氏利什曼原虫无鞭毛体在人类单核细胞中的差异存活情况。
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Complement interaction with trypanosomatid promastigotes in normal human serum.补体与正常人血清中锥虫前鞭毛体的相互作用。
J Exp Med. 2002 Feb 18;195(4):451-9. doi: 10.1084/jem.20011319.
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Immune adherence-mediated opsonophagocytosis: the mechanism of Leishmania infection.免疫黏附介导的调理吞噬作用：利什曼原虫感染的机制
J Exp Med. 1999 Jan 4;189(1):25-35. doi: 10.1084/jem.189.1.25.
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Purification and characterization of alpha-toxin produced by Clostridium novyi type A.A型诺维氏梭菌产生的α毒素的纯化与特性分析
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J Immunol. 1983 Oct;131(4):1994-9.
4
Macrophage complement and lectin-like receptors bind Leishmania in the absence of serum.在无血清情况下，巨噬细胞补体和凝集素样受体可结合利什曼原虫。
J Exp Med. 1985 Jul 1;162(1):324-31. doi: 10.1084/jem.162.1.324.
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Leishmania species: mechanisms of complement activation by five strains of promastigotes.利什曼原虫属：五株前鞭毛体补体激活机制
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Evidence that Leishmania donovani utilizes a mannose receptor on human mononuclear phagocytes to establish intracellular parasitism.杜氏利什曼原虫利用人类单核吞噬细胞上的甘露糖受体来建立细胞内寄生关系的证据。
J Immunol. 1986 Jun 15;136(12):4681-8.
7
Roles of CR3 and mannose receptors in the attachment and ingestion of Leishmania donovani by human mononuclear phagocytes.CR3和甘露糖受体在人单核吞噬细胞对杜氏利什曼原虫的黏附和摄取中的作用。
Infect Immun. 1988 Feb;56(2):363-9. doi: 10.1128/iai.56.2.363-369.1988.
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