College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu Province, 225002, China.
College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu Province, 225002, China.
Carbohydr Polym. 2018 Feb 1;181:264-274. doi: 10.1016/j.carbpol.2017.10.067. Epub 2017 Oct 23.
Cellulose-based materials have reached a growing interest for the improvement of biomedicine, due to their good biocompatibility, biodegradability, and low toxicity. Self-assembly is a spontaneous process by which organized structures with particular functions and properties could be obtained without additional complicated processing steps. This article describes the modifications, properties and applications of cellulose and its derivatives, which including a detailed review of representative types of solvents such as NMMO, DMAc/LiCl, some molten salt hydrates, some aqueous solutions of metal complexes, ionic liquids and NaOH-water system etc. The modifications were frequently performed by esterification, etherification, ATRP, RAFT, ROP and other novel methods. Stimuli-responsive cellulose-based materials, such as temperature-, pH-, light- and redox-responsive, were synthesized for their superior performance. Additionally, the applications of cellulose-based materials which can self-assemble into micelles, vesicles and other aggregates, for drug/gene delivery, bioimaging, biosensor, are also discussed.
基于纤维素的材料由于其良好的生物相容性、生物降解性和低毒性，在生物医学领域的应用受到了越来越多的关注。自组装是一种自发的过程，通过该过程可以获得具有特殊功能和特性的有序结构，而无需额外的复杂加工步骤。本文描述了纤维素及其衍生物的修饰、性质和应用，其中详细介绍了 NMMO、DMAc/LiCl、一些熔融盐水合物、一些金属配合物的水溶液、离子液体和 NaOH-水体系等有代表性的溶剂类型。修饰通常通过酯化、醚化、原子转移自由基聚合（ATRP）、可逆加成-断裂链转移聚合（RAFT）、开环聚合（ROP）和其他新方法进行。为了获得更好的性能，合成了对温度、pH 值、光和氧化还原等刺激响应的纤维素基材料。此外，还讨论了能够自组装成胶束、囊泡和其他聚集体的纤维素基材料在药物/基因传递、生物成像、生物传感器等方面的应用。
