Future Industries Institute, University of South Australia, Mawson Lakes, Adelaide, Australia; Cooperative Research Centre for Cell Therapy Manufacturing, University of South Australia, Adelaide, Australia.
Future Industries Institute, University of South Australia, Mawson Lakes, Adelaide, Australia; Cooperative Research Centre for Cell Therapy Manufacturing, University of South Australia, Adelaide, Australia; School of Engineering, University of South Australia, Mawson Lakes, Adelaide, Australia.
Cytotherapy. 2018 Feb;20(2):169-180. doi: 10.1016/j.jcyt.2017.11.004. Epub 2017 Dec 15.
This review aims to provide a broad introduction to the use of cell sheets and the role of materials in the delivery of cell sheets to patients within a clinical setting. Traditionally, cells sheets have been, and currently are, fabricated using established and accepted cell culture methods within standard formats (e.g., petri dishes) utilizing biological substrates. Synthetic surfaces provide a far more versatile system for culturing and delivering cell sheets. This has the potential to positively affect quality, and efficient, localized cell delivery has a significant impact on patient outcome and on the overall cost of goods. We highlight current applications of these advanced carriers and future applications of these surfaces and cell sheets with an emphasis both on clinical use and regulatory requirements.
本综述旨在广泛介绍细胞片的使用以及在临床环境中将细胞片递送给患者时材料的作用。传统上，细胞片一直并正在使用既定的和被接受的细胞培养方法在标准格式（例如，培养皿）中利用生物基质来制造。合成表面为培养和递送细胞片提供了一个更加多样化的系统。这有可能积极影响质量，并且有效的局部细胞递送对患者的结果和总体货物成本都有重大影响。我们重点介绍了这些先进载体的当前应用以及这些表面和细胞片的未来应用，既强调临床应用又强调监管要求。
