Luo Xinyu, Niu Jiayue, Su Guanyu, Zhou Linxi, Zhang Xue, Liu Ying, Wang Qiang, Sun Ningning
Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, No. 117 Nanjing North Street, Shenyang, 110001, China.
Department of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Biol Eng. 2023 Nov 23;17(1):72. doi: 10.1186/s13036-023-00382-4.
Biomimetic materials are able to mimic the structure and functional properties of native tissues especially natural oral tissues. They have attracted growing attention for their potential to achieve configurable and functional reconstruction in oral medicine. Though tremendous progress has been made regarding biomimetic materials, significant challenges still remain in terms of controversy on the mechanism of tooth tissue regeneration, lack of options for manufacturing such materials and insufficiency of in vivo experimental tests in related fields. In this review, the biomimetic materials used in oral medicine are summarized systematically, including tooth defect, tooth loss, periodontal diseases and maxillofacial bone defect. Various theoretical foundations of biomimetic materials research are reviewed, introducing the current and pertinent results. The benefits and limitations of these materials are summed up at the same time. Finally, challenges and potential of this field are discussed. This review provides the framework and support for further research in addition to giving a generally novel and fundamental basis for the utilization of biomimetic materials in the future.
仿生材料能够模拟天然组织尤其是天然口腔组织的结构和功能特性。它们因其在口腔医学中实现可配置和功能性重建的潜力而受到越来越多的关注。尽管在仿生材料方面已经取得了巨大进展，但在牙齿组织再生机制的争议、制造此类材料的选择有限以及相关领域体内实验测试不足等方面，仍然存在重大挑战。在这篇综述中，系统总结了口腔医学中使用的仿生材料，包括牙齿缺损、牙齿缺失、牙周疾病和颌面骨缺损。回顾了仿生材料研究的各种理论基础，介绍了当前的相关成果。同时总结了这些材料的优点和局限性。最后，讨论了该领域的挑战和潜力。这篇综述为进一步研究提供了框架和支持，同时为未来仿生材料的应用提供了一个总体新颖且基础的依据。
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