Cho Mi Hyeon, Choi Eun-Seok, Kim Sehee, Goh Sung-Ho, Choi Yongdoo
Biomarker Branch, National Cancer Center, Goyang, South Korea.
Therapeutic Target Discovery Branch, National Cancer Center, Goyang, South Korea.
Front Chem. 2017 Dec 4;5:109. doi: 10.3389/fchem.2017.00109. eCollection 2017.
In this study, we synthesized manganese dioxide nanoparticles (MnO NPs) stabilized with biocompatible polymers (polyvinylpyrrolidone and polyacrylic acid) and analyzed their effect on non-small cell lung cancer (NSCLC) cells with or without gefitinib resistance . MnO NPs showed glutathione (GSH)-responsive dissolution and subsequent enhancement in magnetic resonance (MR) imaging. Of note, treatment with MnO NPs induced significant cytotoxic effects on NSCLC cells, and additional dose-dependent therapeutic effects were obtained upon X-ray irradiation. Normal cells treated with MnO NPs were viable at the tested concentrations. In addition, increased therapeutic efficacy could be achieved when the cells were treated with MnO NPs in hypoxic conditions. Therefore, we conclude that the use of MnO NPs in MR imaging and combination radiotherapy may be an efficient strategy for the imaging and therapy of NSCLC.
在本研究中，我们合成了用生物相容性聚合物（聚乙烯吡咯烷酮和聚丙烯酸）稳定的二氧化锰纳米颗粒（MnO NPs），并分析了它们对有或没有吉非替尼耐药性的非小细胞肺癌（NSCLC）细胞的影响。MnO NPs表现出对谷胱甘肽（GSH）响应的溶解以及随后磁共振（MR）成像增强。值得注意的是，MnO NPs处理对NSCLC细胞诱导了显著的细胞毒性作用，并且在X射线照射后获得了额外的剂量依赖性治疗效果。用MnO NPs处理的正常细胞在测试浓度下是存活的。此外，当细胞在缺氧条件下用MnO NPs处理时，可以实现更高的治疗效果。因此，我们得出结论，MnO NPs在MR成像和联合放疗中的应用可能是NSCLC成像和治疗的有效策略。
