Jiang Zhi-Hua, Liu Yan-Ping, He Miao, Zhao Jin-Hua, Wang Ting-Ting, Feng Xing-Yang, Yue Hao, An Ren-Bo, Fu Yan-Hui
a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou , P. R. China.
c College of Pharmacy , Fujian University of Traditional Chinese Medicine , Fuzhou , P. R. China.
Nat Prod Res. 2018 Oct;32(20):2418-2423. doi: 10.1080/14786419.2017.1416379. Epub 2017 Dec 19.
A new abietane diterpenoid, tripterregeline A (1), together with six known diterpenoids (2-7), were isolated from the roots of Tripterygium regelii. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1-7 showed significant inhibitory effects against various human cancer cell lines with IC values ranging from 0.58 to 21.06 μM.
从雷氏雷公藤的根中分离出一种新的枞酸型二萜化合物雷公藤瑞灵素A（1），以及六种已知的二萜化合物（2 - 7）。通过广泛的光谱方法阐明了化合物1的结构，并通过与文献报道的数据进行比较鉴定了已知化合物。对所有分离得到的化合物进行了体外抗五种人类癌细胞系（HL - 60、SMMC - 7721、A - 549、MCF - 7和SW480）的细胞毒性评估。化合物1 - 7对各种人类癌细胞系显示出显著的抑制作用，IC值范围为0.58至21.06 μM。
