Nascimento Milena S, Espindola Carolina F, do Prado Cristiane, Amarins Melina Blanco, Potenza Ana Lucia, Pacheco Luciana, Santos Erica, Vieira Teresa Cristina A
Departamento of Pediatrics, CTIP-Centro de Terapia Intensiva Pediátrica, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627-701, São Paulo, 05651-901 Brazil.
Department of Pediatrics, Hospital Darcy Vargas, São Paulo, Brazil.
Diabetol Metab Syndr. 2017 Dec 16;9:100. doi: 10.1186/s13098-017-0300-7. eCollection 2017.
Type 1 diabetes patients have a higher risk of developing hypoglycemia or hyperglycemia during physical activity, which may compromise their safety during exercise but results regarding the exercise capacity of patients with type 1 DM when compared to control subjects have been contradictory.
To evaluate if type 1 diabetes affects the capacity of adolescents to exercise.
The study enrolled 37 adolescents in stage 2-4 of the Tanner scale, aged from 10 to 14 years, 21 with type 1 diabetes and 16 without any chronic diseases. All subjects performed an incremental submaximal exercise test in a cycle ergometer. At the end of every test stage, glycemia and blood lactate levels were measured. During the test, heart rate was monitored and the Borg rating of perceived exertion (RPE) was used to assess fatigue.
The two groups displayed no significant differences in anthropometric variables. The response to exercise, as evaluated by Borg RPE (p = 0.829), maximum oxygen uptake (VOmax) (p = 0.977), heart rate (p = 0.998), maximum load (p = 0.977), absolute load at lactate threshold (p = 0.377) and relative load at lactate threshold (p = 0.282), was also similar between the control and the type 1 diabetes group. Finally, there were no significant correlations between HbA levels, VOmax, duration of disease and pre-test glycemia levels.
We detected no significant differences in lactate threshold, VOmax and heart rate during exercise between healthy adolescents and non-sedentary adolescents with type I diabetes, indicating that both groups had similar physical fitness and, therefore, that type 1 diabetes is not an obstacle for physical activity. This study was approved by the ethical committee of the Hospital Israelita Albert Einstein (Ethical Committee Number: 53638416.9.0000.0071) and free and informed consent was obtained from all participants and their legal representatives.
1型糖尿病患者在体育活动期间发生低血糖或高血糖的风险较高，这可能会损害他们运动时的安全性，但与对照组相比，1型糖尿病患者运动能力的研究结果相互矛盾。
评估1型糖尿病是否会影响青少年的运动能力。
该研究招募了37名处于坦纳量表2 - 4期的青少年，年龄在10至14岁之间，其中21名患有1型糖尿病，16名无任何慢性疾病。所有受试者在自行车测力计上进行递增亚极量运动试验。在每个测试阶段结束时，测量血糖和血乳酸水平。在测试过程中，监测心率，并使用伯格主观用力程度分级（RPE）来评估疲劳程度。
两组在人体测量学变量方面无显著差异。通过伯格RPE（p = 0.829）、最大摄氧量（VOmax）（p = 0.977）、心率（p = 0.998）、最大负荷（p = 0.977）、乳酸阈时的绝对负荷（p = 0.377）和乳酸阈时的相对负荷（p = 0.282）评估的运动反应，在对照组和1型糖尿病组之间也相似。最后，糖化血红蛋白（HbA）水平、VOmax、病程和测试前血糖水平之间无显著相关性。
我们发现健康青少年和非久坐的1型糖尿病青少年在运动期间的乳酸阈、VOmax和心率方面无显著差异，这表明两组的身体素质相似，因此1型糖尿病并非体育活动的障碍。本研究经以色列阿尔伯特·爱因斯坦医院伦理委员会批准（伦理委员会编号：53638416.9.0000.0071），并获得了所有参与者及其法定代表人的自由和知情同意。
