Hiraoka T
Department of Obstetrics and Gynecology, Hirosaki University School of Medicine.
Nihon Sanka Fujinka Gakkai Zasshi. 1989 Jan;41(1):20-6.
Catecholamine concentrations were measured in urine obtained from pregnant women to estimate the stress resulting from their lifestyles. Adrenaline and noradrenaline were analysed by high performance liquor chromatography (HPLC), creatinine was measured by Jaffe's method, and the catecholamine-creatinine ratio in urine was calculated. Adrenaline concentrations in 24-hour urine were higher in working women (n = 35) than non-working women (n = 20) (p less than 0.001) and the admission group (n = 20) (p less than 0.05), but noradrenaline concentrations showed no significant difference among three groups. Catecholamine concentrations were measured in 89 pregnant women three times in 24 hours. Marked circadian variations were observed with adrenaline and noradrenaline. Both concentrations were lowest in early morning, and increased after work (or evening) (p less than 2.0 X 10(-8)). Adrenaline concentrations were decreased on retiring to bed (p not equal to 1.0 X 10(-5)), while noradrenaline concentrations remained high until retiring to bed. There seems to be a relationship between catecholamine output and working or the familial factor. In working women (n = 53), noradrenaline concentrations were higher than in non-working women (n = 36) in early morning (p less than 0.05) and on retiring to bed (p less than 0.05). On the other hand, in women living with parents (n = 56), adrenaline concentrations were higher than those in women living without parents (n = 33) in early morning (p less than 0.05) and on retiring to bed (p less than 0.05). From these results, it may be concluded that working women or women living with parents are under much stress in their lives.
测量了孕妇尿液中的儿茶酚胺浓度，以评估其生活方式所产生的压力。通过高效液相色谱法（HPLC）分析肾上腺素和去甲肾上腺素，采用杰氏法测量肌酐，并计算尿中儿茶酚胺与肌酐的比值。职业女性（n = 35）24小时尿中肾上腺素浓度高于非职业女性（n = 20）（p < 0.001）和入院组（n = 20）（p < 0.05），但三组间去甲肾上腺素浓度无显著差异。在89名孕妇中，于24小时内三次测量儿茶酚胺浓度。观察到肾上腺素和去甲肾上腺素存在明显的昼夜变化。两者浓度均在清晨最低，工作后（或傍晚）升高（p < 2.0×10⁻⁸）。上床睡觉时肾上腺素浓度降低（p ≠ 1.0×10⁻⁵），而去甲肾上腺素浓度在上床睡觉前一直保持较高水平。儿茶酚胺分泌量与工作或家庭因素之间似乎存在关联。在职业女性（n = 53）中，清晨（p < 0.05）和上床睡觉时（p < 0.05）去甲肾上腺素浓度高于非职业女性（n = 36）。另一方面，与父母同住的女性（n = 56）清晨（p < 0.05）和上床睡觉时（p < 0.05）肾上腺素浓度高于不与父母同住的女性（n = 33）。从这些结果可以得出结论，职业女性或与父母同住的女性在生活中承受着较大压力。
