Bulens C, Meerwaldt J D, van der Wildt G J, Keemink C J
Department of Neurology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
J Neurol Neurosurg Psychiatry. 1989 Mar;52(3):341-5. doi: 10.1136/jnnp.52.3.341.
The influence of stimulus orientation on contrast sensitivity function was studied in 10 patients with drug-induced Parkinsonism. Nine of the 10 patients had at least one eye with contrast sensitivity deficit for vertical and/or horizontal stimuli. Only generalised contrast sensitivity loss, observed in two eyes, was stimulus orientation independent. All spatial frequency-selective contrast deficits in 15 eyes were orientation dependent. The striking similarity between the pattern of contrast sensitivity loss in drug-induced Parkinsonism and that in idiopathic Parkinson's disease, suggests that generalised dopaminergic deficiency, from whatever cause, affects visual function in an analogous way.
在10例药物性帕金森病患者中研究了刺激方向对对比敏感度函数的影响。10例患者中有9例至少一只眼睛对垂直和/或水平刺激存在对比敏感度缺陷。仅在两只眼睛中观察到的全身性对比敏感度丧失与刺激方向无关。15只眼睛中所有空间频率选择性对比缺陷均与方向有关。药物性帕金森病中对比敏感度丧失模式与特发性帕金森病中的模式惊人相似，这表明无论何种原因导致的全身性多巴胺能缺乏，都以类似方式影响视觉功能。
